Evidence map›Paper›PMID 33199591›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Thirst recruits phasic dopamine signaling through subfornical organ neurons.

Ted M Hsu, Paula Bazzino, Samantha J Hurh, Vaibhav R Konanur, Jamie D Roitman, Mitchell F Roitman

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  13. Striatal Serotonin Release Signals Reward Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Dysregulation of the fluid homeostasis system by aging.bioRxiv : the preprint server for biology · 2024
    Article
  16. Fluid transitions.Neuropharmacology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Thirst: neuroendocrine regulation in mammals.Veterinary research communications · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ted M HsuDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607.
Paula BazzinoDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-4012-4337
Samantha J HurhDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-2638-2647
Vaibhav R KonanurDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-7066-9370
Jamie D RoitmanDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607.
Mitchell F RoitmanDepartment of Psychology, University of Illinois at Chicago, Chicago, IL 60607; mroitman@uic.edu.
University of Illinois Chicago · US

Funding

Modulation of NAc-DA Signaling by Learning Motivational State and PeptidesR01DA025634 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROITMAN, MITCHELL F · 2009 to 2024
$5.1M
UIC Portal to Biomedical Research Careers (UIC PBRC) PREPR25GM121212 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALFONSO, AIXA, FEDERLE, MICHAEL J · 2018 to 2024
$1.8M
The effects of context and physiological state on mesolimbic encoding of rewardF32DA047052 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HSU, TED · 2019 to 2021
$209k
NIDA NIH HHS F32 DA047052NIDA NIH HHS R01 DA025634NIGMS NIH HHS R25 GM121212
6 · The paper itself

Abstract

Thirst is a highly potent drive that motivates organisms to seek out and consume balance-restoring stimuli. The detection of dehydration is well understood and involves signals of peripheral origin and the sampling of internal milieu by first order homeostatic neurons within the lamina terminalis-particularly glutamatergic neurons of the subfornical organ expressing CaMKIIa (SFO

Indexed as

Signal TransductionAnimalsBehavior, AnimalBiomarkersCuesDopamineDopaminergic NeuronsElectrophysiological PhenomenaEvoked PotentialsFemaleImmunohistochemistryMaleMotivationRatsReinforcement, PsychologySubfornical OrganBiomarkersDopaminefiber photometryhomeostasismotivationrewardventral tegmental area

Identifiers

PMID33199591
PMCPMC7720158
OpenAlexW3099226654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.