Evidence map›Paper›PMID 33199522›Full record

ArticleJournal of cell science2020

Disrupting polycystin-2 EF hand Ca

Thuy N Vien, Leo C T Ng, Jessica M Smith, Ke Dong, Matteus Krappitz, Vladimir G Gainullin, Sorin Fedeles, Peter C Harris, Stefan Somlo, Paul G DeCaen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Polycystin Channel Complexes.Annual review of physiology · 2023
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Thuy N VienDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Leo C T NgDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jessica M SmithDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Ke DongDepartments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Matteus KrappitzDepartments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Vladimir G GainullinDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Sorin FedelesDepartments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Peter C HarrisDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Stefan SomloDepartments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Paul G DeCaenDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA paul.decaen@northwestern.edu.ORCID 0000-0001-8776-983X
Yale University · USMayo Clinic · USNorthwestern University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8M
Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8M
ADPKD:Disease Spectrum &Genotype-Phenotype CorrelationsR01DK058816 · NIDDK · MAYO CLINIC ROCHESTER · PI Peter C. Harris · 2001 to 2026
$11.3M
Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variantsR01DK123463 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2019 to 2023
$2.0M
Mechanisms of Polycystin and Cilia Function in ADPKDR01DK100592 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2013 to 2017
$1.8M
The genetic identity of the primary cilia ion channels of kidney collecting duct cells and their regulation by internal calciumR00DK106655 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2017 to 2019
$742k
The mechanistic impact of Finger 1 variants on polycystin-2 (PKD2) channels in the primary ciliaR56DK119709 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2018 to 2018
$138k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK079310NIDDK NIH HHS P30 DK090728NIDDK NIH HHS R00 DK106655NIDDK NIH HHS R01 DK058816NIDDK NIH HHS R01 DK100592NIDDK NIH HHS R01 DK123463NIDDK NIH HHS R56 DK119709
6 · The paper itself

Abstract

Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in

Indexed as

Polycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesAnimalsCiliaEF Hand MotifsMiceTRPP Cation ChannelsTRPP Cation ChannelsADPKDBiophysicsCa2+ regulationIon channelsPolycystinPrimary cilia

Identifiers

PMID33199522
PMCPMC7774883
OpenAlexW3099649698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.