Evidence map›Paper›PMID 33199386›Full record

ArticleAntimicrobial agents and chemotherapy2021

The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens.

G L Drusano, Sarah Kim, Mohammed Almoslem, Stephan Schmidt, D Z D'Argenio, Jenny Myrick, Brandon Duncanson, Jocelyn Nole, David Brown, C A Peloquin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Analyzing Pharmacodynamic Count Data That Rapidly Decrease to Zero.CPT: pharmacometrics & systems pharmacology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Delamanid or pretomanid? A Solomonic judgement!The Journal of antimicrobial chemotherapy · 2022
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

G L DrusanoInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA gdrusano@ufl.edu.ORCID 0000-0001-9162-7332
Sarah KimCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.ORCID 0000-0002-9179-0735
Mohammed AlmoslemCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Stephan SchmidtCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
D Z D'ArgenioDepartment of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
Jenny MyrickInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Brandon DuncansonInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Jocelyn NoleInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
David BrownInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
C A PeloquinInfectious Diseases Pharmacokinetics Laboratory, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-9002-7052
Michael NeelyUniversity of Southern California, Los Angeles Children's Hospital, Los Angeles, California, USA.
Walter YamadaUniversity of Southern California, Los Angeles Children's Hospital, Los Angeles, California, USA.
Arnold LouieInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.

Funding

TrainingP41EB001978 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHOO, MICHAEL C K · 2003 to 2017
$18.1M
Optimizing Combination Therapy to Accelerate Clinical Cure of TuberculosisP01AI123036 · NIAID · UNIVERSITY OF FLORIDA · PI DRUSANO, GEORGE LOUIS · 2016 to 2020
$12.0M
Rapid Identification of Optimal Combination Regimens for Pseudomonas aeruginosaR01AI121430 · NIAID · UNIVERSITY OF FLORIDA · PI DRUSANO, GEORGE LOUIS, LOUIE, ARNOLD · 2016 to 2020
$4.1M
NIAID NIH HHS P01 AI123036NIAID NIH HHS R01 AI121430NIBIB NIH HHS P41 EB001978
6 · The paper itself

Abstract

The

Indexed as

Mycobacterium tuberculosisTuberculosisAnimalsAntitubercular AgentsDrug CombinationsDrug Therapy, CombinationHumansAntitubercular AgentsDrug Combinationscombination therapyGreco modelmetabolic stateMycobacterium tuberculosis

Identifiers

PMID33199386
PMCPMC7848982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.