Evidence map›Paper›PMID 33199369›Full record

ArticleThe Journal of biological chemistry

Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori.

Karina A Baksh, Dmitry Pichugin, Robert Scott Prosser, Deborah B Zamble

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Insights into the Orchestration of Gene Transcription Regulators inInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Karina A BakshDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Dmitry PichuginDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Robert Scott ProsserDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: scott.prosser@utoronto.ca.
Deborah B ZambleDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nickel is essential for the survival of the pathogenic bacteria Helicobacter pylori in the fluctuating pH of the human stomach. Due to its inherent toxicity and limited availability, nickel homeostasis is maintained through a network of pathways that are coordinated by the nickel-responsive transcription factor NikR. Nickel binding to H. pylori NikR (HpNikR) induces an allosteric response favoring a conformation that can bind specific DNA motifs, thereby serving to either activate or repress transcription of specific genes involved in nickel homeostasis and acid adaptation. Here, we examine how nickel induces this response using

Indexed as

Allosteric RegulationBacterial ProteinsCrystallography, X-RayDNA, BacterialHelicobacter pyloriNickelNuclear Magnetic Resonance, BiomolecularProtein BindingProtein ConformationRepressor ProteinsThermodynamicsBacterial ProteinsDNA, BacterialNickelNikR protein, Helicobacter pyloriRepressor Proteinsallosteric regulationbacterial transcriptionDNA-binding proteinmetal homeostasismetalloproteinnickelnuclear magnetic resonance (NMR)structure–functiontranscription factor

Identifiers

PMID33199369
PMCPMC7949043
OpenAlexW3102448007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.