Evidence map›Paper›PMID 33199334›Full record

ArticleClinical medicine (London, England)2020

Lessons of the month: A breathless severe asthmatic in the genomic era: Occam's razor or Hickam's dictum?

Carmen Venegas, Sarah Svenningsen, Melanie Kjarsgaard, Mark Tarnopolsky, Kim Anderson, Sebastian Levesque, Benjamin A Raby, Grace Parraga, Gerard Cox, Parameswaran Nair

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Clinical medicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Carmen VenegasSt Joseph's Healthcare, Hamilton, Canada and McMaster University, Hamilton, Canada.
Sarah SvenningsenSt Joseph's Healthcare, Hamilton, Canada and McMaster University, Hamilton, Canada.
Melanie KjarsgaardSt Joseph's Healthcare, Hamilton, Canada.
Mark Tarnopolskyneuromuscular disorders and rehabilitation medicine, McMaster University, Hamilton, Canada.
Kim AndersonDalhousie University, Halifax, Canada.
Sebastian LevesqueUniversité de Sherbrooke, Sherbrooke, Canada.
Benjamin A RabyBoston Children's Hospital, Boston, USA and Harvard University, Boston, USA.
Grace ParragaWestern University, London, Canada.
Gerard CoxSt Joseph's Healthcare, Hamilton, Canada and McMaster University, Hamilton, Canada.
Parameswaran NairSt Joseph's Healthcare, Hamilton, Canada and McMaster University, Hamilton, Canada parames@mcmaster.ca.
McMaster University · CASt. Joseph’s Healthcare Hamilton · CABoston Children's Hospital · USDalhousie University · CAUniversité de Sherbrooke · CAWestern University · CA

Funding

CIHR
6 · The paper itself

Abstract

Breathlessness is a subjective symptom that may stem from a number of pathological and functional aetiologies. Consequently, clinicians are often faced with the challenge of navigating between the tensions of Occam's razor (parsimonious aetiology) or Hickam's dictum (multiple diagnoses). We report a case of a 36-year-old woman with a lifelong history of episodic breathlessness caused at various times by dysfunctions of lung parenchyma (emphysema) and airway smooth muscle (asthma), skeletal muscle (filamin-C fibrillary myopathy) and cardiac muscle (cardiomyopathy). We illustrate the utility of the modern diagnostic toolbox in the assessment, understanding and management of complex dyspnoea (including the use of inflammometry, inhaled-gas magnetic resonance imaging-guided bronchial thermoplasty, and genetic testing), and also demonstrate the importance of interdisciplinary data interpretation in establishing accurate aetiologic diagnoses.

Indexed as

AsthmaLung NeoplasmsAdultDyspneaFemaleGenomicsHumansLungAsthmabreathlessnesscardiomyopathyinhaled-gas MRImyofibrillar myopathy

Identifiers

PMID33199334
PMCPMC7687324
OpenAlexW3105619653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.