SynthesiseLife2020
Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications.
Synthesis in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for in vivo mouse models of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2021Guideline
- Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications.eLife · 2020Pooled it
- Tumor necrosis factor-α-stimulated gene 6 promotes hematoma clearance after intracerebral hemorrhage in a mouse model.Neural regeneration research · 2026Article
- Seasonal trends in sperm quality in Denmark and Florida.Reproductive biology and endocrinology : RB&E · 2026Observational
- Article
- Sexual Dimorphism in Fin Size and Shape in Bluefin Killifish.Ecology and evolution · 2026Article
- New approaches to meta-analyze differences in skewness, kurtosis, and correlation.PLoS biology · 2026Article
- A visualization tool for individual gene expression profiles among males and females in GTEx tissues.Biology of sex differences · 2025Article
- Continental Patterns of Phenotypic Variation Along Replicated Urban Gradients: A Mega-Analysis.Ecology letters · 2025Review
- A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.Biology of sex differences · 2025Article
- ComBatLS: A Location- and Scale-Preserving Method for Multi-Site Image Harmonization.Human brain mapping · 2025Article
- A comparison of cognitive decline in aged mice and mice treated with aftin-4.Scientific reports · 2024Article
- Does greater variation reside in the larger sex?Biology letters · 2024Article
- ComBatLS: A location- and scale-preserving method for multi-site image harmonization.bioRxiv : the preprint server for biology · 2024Article
- Evolution and genetic architecture of sex-limited polymorphism in cuckoos.Science advances · 2024Article
- Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain.Nucleic acids research · 2024Article
- Genetic variation for sexual dimorphism in developmental traits in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Article
- Article
- Temperature and nutrition do not interact to shape the evolution of metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Biomedical and clinical sciences are experiencing a renewed interest in the fact that males and females differ in many anatomic, physiological, and behavioural traits. Sex differences in trait variability, however, are yet to receive similar recognition. In medical science, mammalian females are assumed to have higher trait variability due to estrous cycles (the 'estrus-mediated variability hypothesis'); historically in biomedical research, females have been excluded for this reason. Contrastingly, evolutionary theory and associated data support the 'greater male variability hypothesis'. Here, we test these competing hypotheses in 218 traits measured in >26,900 mice, using meta-analysis methods. Neither hypothesis could universally explain patterns in trait variability. Sex bias in variability was trait-dependent. While greater male variability was found in morphological traits, females were much more variable in immunological traits. Sex-specific variability has eco-evolutionary ramifications, including sex-dependent responses to climate change, as well as statistical implications including power analysis considering sex difference in variance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.