ArticleKnee surgery & related research2020
Is there an optimal age for total knee arthroplasty?: A systematic review.
Article in Knee surgery & related research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exosome-Laden Scaffolds for Treatment of Post-Traumatic Cartilage Injury and Osteoarthritis of the Knee: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Costs and models used in the economic analysis of Total Knee Replacement (TKR): A systematic review.PloS one · 2023Pooled it
- Functional Capacity at Rehabilitation Discharge Predicts Physical Activity Characteristics 24 Weeks Later for People With Total Knee Arthroplasty: A Secondary Analysis of a Randomized Controlled Trial.Archives of physical medicine and rehabilitation · 2025Trial
- Article
- Cell-based therapy injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Younger age doubles medium-term revision risk after total knee arthroplasty: A nationwide multicenter cohort of 5980 knees from the French SCORE I registry.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Assessment of enhanced recovery after surgery protocol in older adults undergoing total knee arthroplasty.Medicine · 2026Article
- High Tibial Osteotomy for Knee Osteoarthritis with Genu Varum: A Retrospective, Observational Study.Journal of functional morphology and kinesiology · 2026Article
- Association between regional anaesthesia strategies, postoperative pain and same-day discharge following knee arthroplasty: a single-centre service evaluation.BMC anesthesiology · 2026Article
- Exploring the optimal age for total knee arthroplasty to minimize risk of adverse outcomes: machine learning analysis of a statewide cohort.Arthroplasty (London, England) · 2026Article
- Effect of high-pressure pulsatile lavage versus manual rinsing on bone cement penetration in total knee arthroplasty: a randomized clinical trial.Knee surgery & related research · 2025Article
- Osteoarthritis and Total Joint Arthroplasty in Housing-Insecure Patients at a Safety Net Hospital in a Major Urban City.Arthroplasty today · 2025Article
- Article
- Treatment decisions and surgery variables are predictors of better physical function after total hip and knee arthroplasty: a retrospective cohort study.Arthroplasty (London, England) · 2025Article
- Soluble CCR2-Expressing Mesenchymal Stem Cells Inhibit Osteoarthritis Development and Progression.Immune network · 2025Article
- Perioperative and Follow-Up Analyses of Primary Posterior Stabilized and Cruciate Retaining Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Predictive analysis of economic and clinical outcomes in total knee arthroplasty: Identifying high-risk patients for increased costs and length of stay.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Indications and outcomes in bi-unicondylar knee arthroplasty: A systematic review.Journal of experimental orthopaedics · 2025Review
- Article
- Analysis of Synovial Fluid Metabolic Profile in Patients with Knee Osteoarthritis Using Spectroscopic Magnetic Resonance Metabolomics.Revista brasileira de ortopedia · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this systematic review was to elucidate the optimal age for patients undergoing total knee arthroplasty (TKA), to optimize the balance between the benefits and risks by analyzing patient-reported outcome measurements (PROM), revision rate, and mortality according to age. MATERIALS AND
methodsA rigorous and systematic approach was used and each of the selected studies was evaluated for methodological quality. Data were extracted according to the following: study design, patients enrolled, patient age at the time of surgery, follow-up period, PROM, revision rate, and mortality.
resultsThirty-nine articles were included in the final analysis. The results were inconsistent in the PROM analysis, but there was consensus that PROM were good in patients in their 70s . In the revision rate analysis, there was consensus that the revision rate tends to increase in TKA in younger patients, but no significant difference was observed in patients > 70 years of age. In the mortality analysis, there was consensus that the mortality was not significantly different in patients < 80 years of age, but tended to increase with age.
conclusionThis systematic review shows that the PROM were good when TKA was performed in patients between 70 and 80 years of age; the best PROM could be achieved around 70 years of age, and no significant difference in the revision or mortality rates was observed between 70 and 80 years of age; however, mortality tended to increase with age. Therefore, the early 70s could be recommended as an optimal age to undergo TKA.
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