Evidence map›Paper›PMID 33198760›Full record

ArticleParticle and fibre toxicology2020

Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults.

Lauren H Wyatt, Robert B Devlin, Ana G Rappold, Martin W Case, David Diaz-Sanchez

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03232086 (Responses to Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Adults), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03232086 nacompletednot on this map

Responses to Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Adults

TypeinterventionalSponsorEnvironmental Protection Agency (EPA)Ran2017 to 2020Enrolled20ConditionsExposure to PollutionArmsClean Air, PM2.5
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Article
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Associations between source-apportioned PMEnvironmental research · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lauren H WyattPublic Health and Integrated Toxicology Division, Human Studies Facility, United States Environmental Protection Agency (USEPA), Research Triangle Park, 104 Mason Farm Rd, Chapel Hill, NC, 27514, USA. Wyatt.lauren@epa.gov.ORCID 0000-0002-4926-2058
Robert B DevlinPublic Health and Integrated Toxicology Division, Human Studies Facility, United States Environmental Protection Agency (USEPA), Research Triangle Park, 104 Mason Farm Rd, Chapel Hill, NC, 27514, USA.
Ana G RappoldPublic Health and Integrated Toxicology Division, Human Studies Facility, United States Environmental Protection Agency (USEPA), Research Triangle Park, 104 Mason Farm Rd, Chapel Hill, NC, 27514, USA.
Martin W CasePublic Health and Integrated Toxicology Division, Human Studies Facility, United States Environmental Protection Agency (USEPA), Research Triangle Park, 104 Mason Farm Rd, Chapel Hill, NC, 27514, USA.
David Diaz-SanchezPublic Health and Integrated Toxicology Division, Human Studies Facility, United States Environmental Protection Agency (USEPA), Research Triangle Park, 104 Mason Farm Rd, Chapel Hill, NC, 27514, USA.
Environmental Protection Agency · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFine particulate matter (PM

methodsTo measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, young volunteers to PM

resultsLow-level PM

conclusionsThis study is the first controlled human exposure study to demonstrate biological effects in response to exposure to concentrated ambient air PM CLINICAL TRIAL REGISTRATION INFORMATION: clinicaltrials.gov ; Identifier: NCT03232086 . The study was registered retrospectively on July 25, 2017, prior to final data collection on October 25, 2017 and data analysis.

Indexed as

AdultAir PollutantsAir PollutionBiomarkersCardiovascular SystemCross-Over StudiesDouble-Blind MethodEnvironmental ExposureFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedParticulate MatterRespiratory Function TestsAir PollutantsBiomarkersParticulate MatterControlled exposureHealthy human volunteersParticulate matter air pollutionSystemic inflammatory effect

Identifiers

PMID33198760
PMCPMC7670817
OpenAlexW3102222774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.