ArticleBMC cancer2020
Accumulation of the delivered dose based on cone-beam CT and deformable image registration for non-small cell lung cancer treated with hypofractionated radiotherapy.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Quantifying the Effect of 4-Dimensional Computed Tomography-Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy.International journal of radiation oncology, biology, physics · 2024Trial
- Does the traffic light protocol capture dose deviations? A longitudinal CBCT-based dose-monitoring study in adaptive RT for LA-NSCLC.Technical innovations & patient support in radiation oncology · 2026Article
- [An unsupervised three-dimensional medical image registration method based on shifted window Transformer and convolutional neural network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Reducing radiation pneumonitis in lung cancer patients: from Chinese expert consensus to practice.Translational lung cancer research · 2025Article
- Time series analysis of dosimetric changes in target volumes and organs at risk monitored by cone beam computed tomography during radiotherapy for non-small-cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- Quantitative evaluation of accumulated and planned dose deviations in patients undergoing gated and non-gated lung stereotactic body radiation therapy patients: a retrospective analysis.Translational lung cancer research · 2024Article
- Robust thoracic CT image registration with environmental adaptability using dynamic Welsch's function and hierarchical structure-awareness strategy.Quantitative imaging in medicine and surgery · 2024Article
- Comparative analysis of delivered and planned doses in target volumes for lung stereotactic ablative radiotherapy.Radiation oncology (London, England) · 2024Article
- Evaluation of dose delivery based on deformed CT using a commercial software for lung cancer.Scientific reports · 2024Article
- Exploration and machine learning model development for T2 NSCLC with bronchus infiltration and obstructive pneumonia/atelectasis.Scientific reports · 2024Article
- Article
- Artificial intelligence neural network analysis and application of CT imaging features to predict lymph node metastasis in non-small cell lung cancer.Journal of thoracic disease · 2022Article
- Machine-learning-based prediction of the effectiveness of the delivered dose by exhale-gated radiotherapy for locally advanced lung cancer: The additional value of geometric over dosimetric parameters alone.Frontiers in oncology · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to quantify the dosimetric differences between the planned and delivered dose to tumor and normal organs in locally advanced non-small cell lung cancer (LANSCLC) treated with hypofractionated radiotherapy (HRT), and to explore the necessity and identify optimal candidates for adaptive radiotherapy (ART).
methodsTwenty-seven patients with stage III NSCLC were enrolled. Planned radiation dose was 51Gy in 17 fractions with cone-beam CT (CBCT) acquired at each fraction. Virtual CT was generated by deformable image registration (DIR) of the planning CT to CBCT for dose calculation and accumulation. Dosimetric parameters were compared between original and accumulated plans using Wilcoxon signed rank test. Correlations between dosimetric differences and clinical variables were analyzed using Mann-Whitney U test or Chi-square test.
resultsPatients had varied gross tumor volume (GTV) reduction by HRT (median reduction rate 11.1%, range - 2.9-44.0%). The V
conclusionsLANSCLC patients treated with HRT had sufficient tumor dose coverage and acceptable normal tissue dose deviation. ART should be applied in patients with quick tumor regression and baseline obstructive pneumonitis/atelectasis to spare more normal structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.