Evidence map›Paper›PMID 33198661›Full record

ArticleBMC cancer2020

Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information.

Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume, Gro Wiedswang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01919151 (The Process of Metastasis in Colorectal Cancer Tumour Biology and Prognostic Factors in Pancreatic Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01919151 unknown statusnot on this map

The Process of Metastasis in Colorectal Cancer Tumour Biology and Prognostic Factors in Pancreatic Cancer

TypeobservationalSponsorOslo University HospitalRan2008 to 2015Enrolled500ConditionsPancreatic Adenocarcinoma, Colorectal Cancer
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Harald HugenschmidtInstitute of Clinical Medicine, University of Oslo, Oslo, Norway. harald@hugenschmidt.net.ORCID http://orcid.org/0000-0002-1114-5366
Knut Jørgen LaboriDepartment of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway.
Cathrine BrunborgOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Caroline Sophie VerbekeInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Lars Thomas SeebergDepartment of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway.
Cecilie Bendigtsen SchirmerDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Anne RenolenDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Elin BorgenDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Bjørn NaumeInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Gro WiedswangDepartment of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a variety of epithelial cancers. In a cohort of patients with presumed resectable pancreatic and periampullary carcinoma, we evaluated the frequency and the potential prognostic impact of the preoperative presence of DTC, defined as cytokeratin-positive cells detected by immunocytochemistry (ICC).

methodsPreoperative BM samples from 242 patients selected for surgical resection of presumed resectable pancreatic and periampullary carcinoma from 09/2009 to 12/2014, were analysed for presence of CK-positive cells by ICC. The median observation time was 21.5 months. Overall survival (OS) and disease-free survival (DFS) were calculated by Kaplan-Meier and Cox regression analysis.

resultsSuccessful resections of malignant tumours were performed in 179 of the cases, 30 patients resected had benign pancreatic disease based on postoperative histology, and 33 were deemed inoperable intraoperatively due to advanced disease. Overall survival for patients with resected carcinoma was 21.1 months (95% CI: 18.0-24.1), for those with benign disease OS was 101 months (95% CI: 69.4-132) and for those with advanced disease OS was 8.8 months (95% CI: 4.3-13.3). The proportion of patients with detected CK-positive cells was 6/168 (3.6%) in resected malignant cases, 2/31 (6.5%) in advanced disease and 4/29 (13.8%) in benign disease. The presence of CK-positive cells was not correlated to OS or DFS, neither in the entire cohort nor in the subgroup negative for circulating tumour cells (CTC).

conclusionsThe results indicate that CK-positive cells may be present in both patients with malignant and benign diseases of the pancreas. Detection of CK-positive cells was not associated with differences in prognosis for the entire cohort or any of the subgroups analysed.

trial registrationclinicaltrials.gov ( NCT01919151 ).

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overAmpulla of VaterBiomarkers, TumorCommon Bile Duct NeoplasmsDuodenal NeoplasmsFemaleFollow-Up StudiesHumansKeratinsMaleMiddle AgedPancreatic NeoplasmsPrognosisBiomarkers, TumorKeratinsBone marrowDisseminated tumour cellsDTCPancreatic cancerPeriampullary cancer

Identifiers

PMID33198661
PMCPMC7667773
OpenAlexW3106092760

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.