ArticleBMC infectious diseases2020
Risk factors associated with death in infants <120 days old with severe pertussis: a case-control study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Influencing factors for severe pertussis among Chinese children: A meta-analysis.Human vaccines & immunotherapeutics · 2026Pooled it
- Variability in the Diagnostic Criteria for Severe Pertussis: A Systematic Review.JAMA network open · 2026Pooled it
- Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.Critical care (London, England) · 2025Pooled it
- Swedish Infants Developed Pertussis at a Younger Age if Their Mother Was the Possible Source of Infection in 2009-2015.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Clinical epidemiological characteristics and risk factors for severe pertussis in children in Xiamen.BMC infectious diseases · 2026Article
- Charcoal agar interference in antibiotic susceptibility testing of Bordetella pertussis: evaluation and alternative methodologies.Annals of clinical microbiology and antimicrobials · 2026Article
- Hypercapnia as a Key Mechanism in the Development of Pulmonary Hypertension in Malignant Pertussis: A Case Report.Respirology case reports · 2026Article
- A retrospective, single-center analysis of clinical features and mortality risk factors in pediatric pertussis patients with severe pneumonia and encephalopathy complications in Southwest China.Italian journal of pediatrics · 2026Article
- Parent-driven transmission, off-label SMZ-TMP, and severe pertussis prediction in infants under 2 months: a real-world observational cohort of 527 cases.Frontiers in pediatrics · 2026Article
- Successful azithromycin desensitization using a modified protocol after initial reaction: A pediatric case report.IDCases · 2026Article
- Clinical and laboratory characteristics of criticalFrontiers in pediatrics · 2026Article
- Clinical characteristics of pertussis in infants and risk factors for respiratory support.Annals of medicine · 2025Article
- Retrospective analysis of 104 cases of pediatric severe pertussis in Southern China.BMC infectious diseases · 2025Article
- Clinical characteristics and prognosis of exchange transfusion in infants with severe pertussis.BMC pediatrics · 2025Article
- Clinical and immunological predictors of severe pertussis in children: a nomogram-based prediction model.BMC infectious diseases · 2025Article
- Beyond Passive Immunity: Three Neonatal Influenza Cases Highlighting Impact of Missed Maternal Vaccination.Clinics and practice · 2025Article
- Clinical and Epidemiological Characteristics of Pediatric Pertussis Cases: A Retrospective Study from Southeast Romania.Antibiotics (Basel, Switzerland) · 2025Article
- Risk factors and mortality in children with severe pertussis: the role of exchange transfusion in a PICU.Italian journal of pediatrics · 2025Article
- Interpretation of guidelines for diagnosis, management, and prevention of pertussis in China (version 2024).Infectious diseases & immunity · 2025Article
- Sources and clinical characteristics of infant pertussis in China: increasing contribution of siblings.BMC infectious diseases · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePertussis is a serious infectious disease in young infants, and severe cases frequently cause death. Our study explored risk factors for death from severe pertussis.
methodA case-control study of infants with severe pertussis admitted to the paediatric intensive care unit (PICU) in the Children's Hospital of Chongqing Medical University, China, from January 1, 2013, to June 30, 2019, was conducted. Pertussis was confirmed by clinical features and laboratory examinations. Severe pertussis was defined as patients with pertussis resulting in PICU admission or death. To understand the risk factors for death, we compared fatal and nonfatal cases of severe pertussis in infants aged < 120 days by collecting clinical and laboratory data.
resultsThe participants included 63 infants < 120 days of age with severe pertussis. Fifteen fatal cases were confirmed and compared with 44 nonfatal severe pertussis cases, Four patients with termination of treatment were excluded. In the univariate analysis, the risk factors associated with death included apnoea (P = 0.001), leukocytosis (white blood cell (WBC) count≥30 × 10
conclusionLeukocytosis and pulmonary hypertension exhibited the greatest associations with death in infants with severe pertussis admitted to the PICU. Vaccination is still the most effective protection method against pertussis.
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