Evidence map›Paper›PMID 33198403›Full record

ArticlePharmaceutics2020

Evaluation of Actinium-225 Labeled Minigastrin Analogue [

Yun Qin, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P Béhé, Michal Grzmil

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Preclinical characterization of 3p-C-DEPAEJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Article
  5. Review
  6. Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Review
  8. Biodistribution Assessment of a NovelLife (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Article
  11. Signaling Network Response to α-Particle-Targeted Therapy with theJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Development of [Pharmaceutics · 2021
    Article
  17. Actinium-225 in Targeted Alpha Therapy.Journal of medical physics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yun QinCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Stefan ImoberstegCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Alain BlancCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Stephan FrankDivision of Neuropathology, Institute of Pathology, University of Basel, 4031 Basel, Switzerland.
Roger SchibliCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Martin P BéhéCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.ORCID 0000-0002-1110-2665
Michal GrzmilCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Paul Scherrer Institute · CHUniversity of Basel · CH

Funding

Krebsliga Schweiz KFS-3960-08-2016-R
6 · The paper itself

Abstract

The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of radiolabeled minigastrin analogues for targeted radionuclide therapy, which aims to deliver cytotoxic radiation specifically to cancer cells. Alpha emitters (e.g., actinium-225) possess high potency in cancer cell-killing and hold promise for the treatment of malignant tumors. In these preclinical studies, we developed and evaluated CCKBR-targeted alpha particle therapy. The cellular uptake and cytotoxic effect of actinium-225 labeled and HPLC-purified minigastrin analogue [

Indexed as

actinium-225cholecystokinin B receptor (CCKBR)minigastrin analogue PP-F11Ntargeted alpha particle therapy (TAT)

Identifiers

PMID33198403
PMCPMC7696055
OpenAlexW3102349765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.