Evidence map›Paper›PMID 33198358›Full record

ArticleMolecules (Basel, Switzerland)2020

Characteristics of Exposure to Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) among Humidifier Disinfectant-Associated Lung Injury (HDLI) Patients in South Korea.

Dong-Uk Park, Seon-Kyung Park, Jiwon Kim, Jihoon Park, Seung-Hun Ryu, Ju-Hyun Park, So-Yeon Lee, Han Bin Oh, Sungkyoon Kim, Kyung Ehi Zoh and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dong-Uk ParkDepartment of Environmental Health, Korea National Open University, Seoul 03087, Korea.ORCID 0000-0003-3847-7392
Seon-Kyung ParkDivision of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Korea.ORCID 0000-0002-4829-5587
Jiwon KimDepartment of Environmental Health, Korea National Open University, Seoul 03087, Korea.
Jihoon ParkAccident Response Division, National Institute of Chemical Safety, Ministry of Environment, Daejeon 34111, Korea.
Seung-Hun RyuHumidifier Disinfectant Health Center, National Institute of Environmental Research, Incheon 22689, Korea.
Ju-Hyun ParkDepartment of Statistics, Dongguk University, Seoul 04620, Korea.
So-Yeon LeeDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Han Bin OhDepartment of Chemistry, Sogang University, Seoul 04107, Korea.ORCID 0000-0001-7919-0393
Sungkyoon KimDepartment of Environmental Health Sciences, Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-1378-8795
Kyung Ehi ZohDepartment of Environmental Health Sciences, Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
Soyoung ParkDepartment of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 03181, Korea.
Jung-Hwan KwonDivision of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Korea.ORCID 0000-0002-6341-7562

Funding

Special Commission on Social Disaster Investigation 12198215600The Korea Ministry of Environment 2018002490001
6 · The paper itself

Abstract

This study aimed to quantify both chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) dissolved in different product brands and to characterize the exposure to these chemicals among humidifier disinfectant-associated lung injury (HDLI) patients. Both CMIT and MIT dissolved in different humidifier disinfectant (HD) products were quantified using gas chromatography-mass spectrometry. The inhalation level of CMIT and MIT was estimated based on HD-associated factors as reported by HDLI patients. A total of eleven HD products marketed until the end of 2011 were found to contain CMIT and/or MIT. The level of combined CMIT and/or MIT dissolved in these HD products ranged from 12 to 353 ppm. The level varied among HD products and the year of manufacture. The average inhalation levels were estimated to be 7.5, 4.1, and 3.2 μg/m

Indexed as

HumidifiersAdultAir PollutantsChildChild, PreschoolDisinfectantsFemaleGas Chromatography-Mass SpectrometryHumansInfantInhalation ExposureLimit of DetectionLungLung InjuryMaleMiddle Aged2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-oneAir PollutantsDisinfectantsThiazoleschloromethylisothiazolinone (CMIT)humidifier disinfectant-associated lung injury (HDLI)humidifier disinfectant (HD)inhalation exposuremethylisothiazolinone (MIT)patient

Identifiers

PMID33198358
PMCPMC7697974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.