Evidence map›Paper›PMID 33198352›Full record

ArticleInternational journal of molecular sciences2020

Three-Dimensional Nuclear Telomere Profiling as a Biomarker for Recurrence in Oligodendrogliomas: A Pilot Study.

Macoura Gadji, Shubha Mathur, Brigitte Bélanger, Jaganmohan Reddy Jangamreddy, Josée Lamoureux, Ana Maria Crous Tsanaclis, David Fortin, Régen Drouin, Sabine Mai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Macoura GadjiDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC J1H 5N4, Canada.ORCID 0000-0003-0252-3772
Shubha MathurDepartments of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Cell Biology, Research Institute of Oncology and Hematology (RIOH), CancerCare Manitoba (CCMB), The Genomic Centre for Cancer Research and Diagnosis (GCCRD), The University of Manitoba, 675 McDermot Avenue, Winnipeg, MB R3E 0V9, Canada.
Brigitte BélangerDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC J1H 5N4, Canada.
Jaganmohan Reddy JangamreddyUR Advanced Therapeutics Pvt Ltd., ASPIRE-BioNEST, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
Josée LamoureuxDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC J1H 5N4, Canada.
Ana Maria Crous TsanaclisDepartment of Pathology and cellular Biology, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada.
David FortinDivision of Neurosurgery, Department of Surgery, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Régen DrouinDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC J1H 5N4, Canada.
Sabine MaiDepartments of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Cell Biology, Research Institute of Oncology and Hematology (RIOH), CancerCare Manitoba (CCMB), The Genomic Centre for Cancer Research and Diagnosis (GCCRD), The University of Manitoba, 675 McDermot Avenue, Winnipeg, MB R3E 0V9, Canada.ORCID 0000-0002-5797-2201
Université de Sherbrooke · CACancerCare Manitoba · CAUniversité de Montréal · CAUniversity of Hyderabad · IN

Funding

Leukemia and Lymphoma Society of Canada 763110142
6 · The paper itself

Abstract

Mechanisms of recurrence in oligodendrogliomas are poorly understood. Recurrence might be driven by telomere dysfunction-mediated genomic instability. In a pilot study, we investigated ten patients with oligodendrogliomas at the time of diagnosis (first surgery) and after recurrence (second surgery) using three-dimensional nuclear telomere analysis performed with quantitative software TeloView

Indexed as

Neoplasm Recurrence, LocalAdultAgedBiomarkers, TumorBiopsyBrain NeoplasmsCell NucleusChromosomes, Human, Pair 1Chromosomes, Human, Pair 19Disease ProgressionFemaleGenomicsHumansImaging, Three-DimensionalIn Situ Hybridization, FluorescenceKaplan-Meier EstimateBiomarkers, Tumorgliomasnuclear organizationoligodendrogliomatelomerethree-dimensional

Identifiers

PMID33198352
PMCPMC7696868
OpenAlexW3103028991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.