Evidence map›Paper›PMID 33198334›Full record

ArticleViruses2020

Identification of Novel Astroviruses in the Gastrointestinal Tract of Domestic Cats.

Kate Van Brussel, Xiuwan Wang, Mang Shi, Maura Carrai, Jun Li, Vito Martella, Julia A Beatty, Edward C Holmes, Vanessa R Barrs

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Kate Van BrusselSchool of Veterinary Science, Faculty of Science, University of Sydney, Sydney, NSW 2006, Australia.
Xiuwan WangDepartment of Infectious Diseases and Public Health, Jockey Club of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, China.ORCID 0000-0002-6955-3733
Mang ShiMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Maura CarraiDepartment of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, China.
Jun LiDepartment of Infectious Diseases and Public Health, Jockey Club of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, China.
Vito MartellaDepartment of Veterinary Medicine, University of Aldo Moro of Bari, 70010 Valenzano, Italy.ORCID 0000-0002-5740-6947
Julia A BeattySchool of Veterinary Science, Faculty of Science, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-6520-7801
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-9596-3552
Vanessa R BarrsSchool of Veterinary Science, Faculty of Science, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-6761-8022
The University of Sydney · AUCity University of Hong Kong · HKUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astroviruses, isolated from numerous avian and mammalian species including humans, are commonly associated with enteritis and encephalitis. Two astroviruses have previously been identified in cats, and while definitive evidence is lacking, an association with enteritis is suggested. Using metagenomic next-generation sequencing of viral nucleic acids from faecal samples, we identified two novel feline astroviruses termed Feline astrovirus 3 and 4. These viruses were isolated from healthy shelter-housed kittens (Feline astrovirus 3; 6448 bp) and from a kitten with diarrhoea that was co-infected with Feline parvovirus (Feline astrovirus 4, 6549 bp). Both novel astroviruses shared a genome arrangement of three open reading frames (ORFs) comparable to that of other astroviruses. Phylogenetic analysis of the concatenated ORFs, ORF1a, ORF1b and capsid protein revealed that both viruses were phylogenetically distinct from other feline astroviruses, although their precise evolutionary history could not be accurately determined due to a lack of resolution at key nodes. Large-scale molecular surveillance studies of healthy and diseased cats are needed to determine the pathogenicity of feline astroviruses as single virus infections or in co-infections with other enteric viruses.

Indexed as

AnimalsAnimals, DomesticAstroviridae InfectionsCat DiseasesCatsComputational BiologyGastroenteritisGenome, ViralGenomicsMaleMamastrovirusPhylogenyRecombination, GeneticSequence Analysis, DNAcapsiddiarrhoeadomestic catsevolutionfeline astrovirusmamastrovirus

Identifiers

PMID33198334
PMCPMC7697530
OpenAlexW3106468298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.