Evidence map›Paper›PMID 33198234›Full record

ReviewBrain sciences2020

p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases.

Artem P Gureev, Irina S Sadovnikova, Natalia N Starkov, Anatoly A Starkov, Vasily N Popov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Artem P GureevDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.ORCID 0000-0003-3562-5329
Irina S SadovnikovaDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.
Natalia N StarkovScience Department, SUNY Maritime College, New York, NY 10465, USA.
Anatoly A StarkovNeuroscience Department, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA.
Vasily N PopovDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.
Voronezh State University · RUCornell University · USSUNY Maritime College · USVoronezh State University of Engineering Technologies · RU

Funding

Ministry of Science and Higher Education of the Russian Federation FZGU-2020-0044Russian Foundation for Basic Research 17-29-06036 ofi_mundefined <span style="color:gray;font-size:10px;">undefined</span> AG014930/AG/NIA
6 · The paper itself

Abstract

Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which is involved in the regulation of the expression of genes responsible for oxidative stress protection, regulation of mitochondrial biogenesis, and mitophagy. The p62 protein is a multifunctional cytoplasmic protein that functions as a selective mitophagy receptor for the degradation of ubiquitinated substrates. There is evidence that p62 can positively regulate Nrf2 by binding to its negative regulator, Keap1. However, there is also strong evidence that Nrf2 up-regulates p62 expression. Thereby, a regulatory loop is formed between two important signaling pathways, which may be an important target for drugs aimed at treating neurodegeneration. Constitutive activation of p62 in parallel with Nrf2 would most likely result in the activation of mTORC1-mediated signaling pathways that are associated with the development of malignant neoplasms. The purpose of this review is to describe the p62-Nrf2-p62 regulatory loop and to evaluate its role in the regulation of mitophagy under various physiological conditions.

Indexed as

mitochondriamitophagyneurodegenerative diseaseNrf2p62regulatory loop

Identifiers

PMID33198234
PMCPMC7696015
OpenAlexW3106132486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.