Evidence map›Paper›PMID 33198121›Full record

ReviewJournal of fungi (Basel, Switzerland)2020

Fungal Pigments and Their Roles Associated with Human Health.

Lan Lin, Jianping Xu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 114 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Plants (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Domestication in dry-cured meatEvolutionary applications · 2023
    Article
  17. The Enigmatic World of Fungal Melanin: A Comprehensive Review.Journal of fungi (Basel, Switzerland) · 2023
    Review
  18. Light effects on Lasiodiplodia theobromae metabolome cultured in vitro.Metabolomics : Official journal of the Metabolomic Society · 2023
    Article
  19. Review
  20. Overview of fungal terpene synthases and their regulation.World journal of microbiology & biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Lan LinSchool of Life Science and Technology, Department of Bioengineering, Key Laboratory of Developmental Genes and Human Diseases (MOE), Southeast University, Nanjing 210096, Jiangsu, China.
Jianping XuDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-2915-2780
McMaster University · CASoutheast University · CN

Funding

China Scholarship Council 2020-2021McMaster University GSI2020-3Natural Sciences and Engineering Research Council of Canada 2020-531998
6 · The paper itself

Abstract

Fungi can produce myriad secondary metabolites, including pigments. Some of these pigments play a positive role in human welfare while others are detrimental. This paper reviews the types and biosynthesis of fungal pigments, their relevance to human health, including their interactions with host immunity, and recent progresses in their structure-activity relationships. Fungal pigments are grouped into carotenoids, melanin, polyketides, and azaphilones, etc. These pigments are phylogenetically broadly distributed. While the biosynthetic pathways for some fungal pigments are known, the majority remain to be elucidated. Understanding the genes and metabolic pathways involved in fungal pigment synthesis is essential to genetically manipulate the production of both the types and quantities of specific pigments. A variety of fungal pigments have shown wide-spectrum biological activities, including promising pharmacophores/lead molecules to be developed into health-promoting drugs to treat cancers, cardiovascular disorders, infectious diseases, Alzheimer's diseases, and so on. In addition, the mechanistic elucidation of the interaction of fungal pigments with the host immune system provides valuable clues for fighting fungal infections. The great potential of fungal pigments have opened the avenues for academia and industries ranging from fundamental biology to pharmaceutical development, shedding light on our endeavors for disease prevention and treatment.

Indexed as

antitumorazaphilonescarotenoidsfungal pigmentsmedical rolesmelaninpolyketides

Identifiers

PMID33198121
PMCPMC7711509
OpenAlexW3102941308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.