Evidence map›Paper›PMID 33197709›Full record

ReviewCurrent opinion in neurobiology2021

Dopamine, Updated: Reward Prediction Error and Beyond.

Talia N Lerner, Ashley L Holloway, Jillian L Seiler

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Sense of agency and decision making.Frontiers in psychology · 2026
    Article
  18. Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025
    Article
  19. Phasic dopamine encodes persistent attraction to reward cues.bioRxiv : the preprint server for biology · 2025
    Article
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Talia N LernerFeinberg School of Medicine and Department of Physiology, Northwestern University, Chicago, IL, USA; Northwestern University Interdepartmental Neuroscience Program, Chicago, IL, USA. Electronic address: talia.lerner@northwestern.edu.
Ashley L HollowayFeinberg School of Medicine and Department of Physiology, Northwestern University, Chicago, IL, USA; Northwestern University Interdepartmental Neuroscience Program, Chicago, IL, USA.
Jillian L SeilerFeinberg School of Medicine and Department of Physiology, Northwestern University, Chicago, IL, USA; Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.

Funding

How Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric DiseaseDP2MH122401 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LERNER, TALIA NEWCOMBE · 2019 to 2022
$2.5M
NIMH NIH HHS DP2 MH122401
6 · The paper itself

Abstract

Dopamine neurons have been intensely studied for their roles in reinforcement learning. A dominant theory of how these neurons contribute to learning is through the encoding of a reward prediction error (RPE) signal. Recent advances in dopamine research have added nuance to RPE theory by incorporating the ideas of sensory prediction error, distributional encoding, and belief states. Further nuance is likely to be added shortly by convergent lines of research on dopamine neuron diversity. Finally, a major challenge is to reconcile RPE theory with other current theories of dopamine function to account for dopamine's role in movement, motivation, and goal-directed planning.

Indexed as

DopamineRewardDopaminergic NeuronsMotivationReinforcement, PsychologyDopamine

Identifiers

PMID33197709
PMCPMC8116345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.