Observational studyRespiratory physiology & neurobiology2021
Diaphragmatic thickening fraction as a potential predictor of response to continuous positive airway pressure ventilation in Covid-19 pneumonia: A single-center pilot study.
Observational study in Respiratory physiology & neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease.Critical care (London, England) · 2021Trial
- Article
- The ability of diaphragmatic excursion after extubation to predict the need for resumption of ventilatory support in critically ill surgical patients.Journal of anesthesia · 2025Observational
- Exploring the adoption of diaphragm and lung ultrasound (DLUS) by physiotherapists, physical therapists, and respiratory therapists: an updated scoping review.The ultrasound journal · 2025Review
- Diaphragm Muscle Atrophy Contributes to Low Physical Capacity in COVID-19 Survivors.Life (Basel, Switzerland) · 2024Article
- Correlation of diaphragm thickening fraction and oesophageal pressure swing in non-invasive ventilation of healthy subjects.BMC pulmonary medicine · 2024Article
- Diaphragm Ultrasound in Different Clinical Scenarios: A Review with a Focus on Older Patients.Geriatrics (Basel, Switzerland) · 2024Review
- Complications during Veno-Venous Extracorporeal Membrane Oxygenation in COVID-19 and Non-COVID-19 Patients with Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2024Article
- Point-of-care ultrasound use in COVID-19: a narrative review.Annals of translational medicine · 2024Review
- Replacement of fluoroscopy by ultrasonography in the evaluation of hemidiaphragm function, an exploratory prospective study.The ultrasound journal · 2024Article
- Lung Ultrasound Score as a Predictor of Failure to Wean COVID-19 Elderly Patients off Mechanical Ventilation: A Prospective Observational Study.Clinical interventions in aging · 2024Observational
- Lung ultrasound score and diaphragm ultrasound in weaning from mechanical ventilation: are they different in patients with and without COVID-19?Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects.Respiration; international review of thoracic diseases · 2024Article
- Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation.Journal of intensive care · 2023Article
- Temporal evolution of diaphragm thickness and diaphragm excursion among subjects hospitalized with COVID-19: A prospective observational study.Respiratory medicine and research · 2023Observational
- Ultrasonographic Assessment of Diaphragmatic Function and Its Clinical Application in the Management of Patients with Acute Respiratory Failure.Diagnostics (Basel, Switzerland) · 2023Review
- Sarcopenia and COVID-19 Outcomes.Clinical interventions in aging · 2023Review
- Effect of inspiratory muscle training on hypoxemia in obese patients undergoing painless gastroscopy: protocol for a single-center, double-blind, randomized controlled trial.Frontiers in medicine · 2023Article
- The role of ultrasound in predicting non-invasive ventilation outcomes: a systematic review.Frontiers in medicine · 2023Article
- Head to toe ultrasound: a narrative review of experts' recommendations of methodological approaches.Journal of anesthesia, analgesia and critical care · 2022Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn a variable number of Covid-19 patients with acute respiratory failure, non-invasive breathing support strategies cannot provide adequate oxygenation, thus making invasive mechanical ventilation necessary. Factors predicting this unfavorable outcome are unknown, but we hypothesized that diaphragmatic weakness may contribute.
methodsWe prospectively analyzed the data of 27 consecutive patients admitted to the general Intensive Care Unit (ICU) from March 19, 2020, to April 20, 2020 and submitted to continuous positive airway pressure (CPAP) before considering invasive ventilation. Diaphragmatic thickening fraction (DTF) inferred by ultrasound was determined before applying CPAP.
resultsEighteen patients recovered with CPAP, whereas nine required invasive mechanical ventilation with longer stay in ICU (p < 0.001) and hospital (p = 0.003). At univariate logistic regression analysis, CPAP failure was significantly associated with low DTF [β: -0.396; OR: 0.673; p < 0.001] and high respiratory rate [β: 0.452; OR: 1.572; p < 0.001] but only DTF reached statistical significance at multivariate analysis [β: -0.384; OR: 0.681; p < 0.001]. The DTF best threshold predicting CPAP failure was 21.4 % (AUC: 0.944; sensitivity: 94.4 %, specificity: 88.9 %).
conclusionsIn critically ill patients with Covid-19 respiratory failure admitted to ICU, a reduced DTF could be a potential predictor of CPAP failure and requirement of invasive ventilation.
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