ArticleChemMedChem2021
Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.
Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Water-Soluble Ammonium BODIPYs: Synthesis, Photophysics, Photogelation, and Antimicrobial Activity.Chemistry, an Asian journal · 2026Article
- Quaternary Ammonium Dimethacrylates as an Additive in Dental Composite Resins: A Review of Their Antimicrobial, Mechanical, and Physicochemical Properties.Materials (Basel, Switzerland) · 2025Review
- Antimicrobial and Biofilm Inhibition Activity of Novel Biobased Quaternary Ammonium Salts.ACS omega · 2025Article
- Designing Antibacterial-Based Quaternary Ammonium Coatings (Surfaces) or Films for Biomedical Applications: Recent Advances.International journal of molecular sciences · 2024Review
- Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds.International journal of molecular sciences · 2024Review
- The effectiveness of newly synthesized quaternary ammonium salts differing in chain length and type of counterion against priority human pathogens.Scientific reports · 2022Article
- Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance.ACS infectious diseases · 2022Article
- An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.ChemMedChem · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
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Registered trials
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