Evidence map›Paper›PMID 33197178›Full record

ArticleJournal of agricultural and food chemistry2020

No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women.

Luying Chen, Jaewoo Choi, Scott W Leonard, Suzanne Banuvar, Elena Barengolts, Marlos Viana, Shao-Nong Chen, Guido F Pauli, Judy L Bolton, Richard B van Breemen

Open access · greenAbstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Enzyme Activity of Natural Products on Cytochrome P450.Molecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Luying ChenLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, Oregon 97331, United States.
Jaewoo ChoiLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, Oregon 97331, United States.
Scott W LeonardLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, Oregon 97331, United States.
Suzanne BanuvarUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.
Elena BarengoltsUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.
Marlos VianaUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.
Shao-Nong ChenUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.ORCID http://orcid.org/0000-0003-0748-0863
Guido F PauliUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.ORCID http://orcid.org/0000-0003-1022-4326
Judy L BoltonUIC/NIH Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, Illinois 60612, United States.
Richard B van BreemenLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, Oregon 97331, United States.ORCID http://orcid.org/0000-0003-2016-0063
University of Illinois Urbana-Champaign · USOregon State University · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Van Breemen: Project 3; Botanical Dietary Supplements - Metabolism and Safety in Women (Van Breemen)P50AT000155 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 1999 to 2019
$30.4M
NCATS NIH HHS UL1 TR002003NCCIH NIH HHS P50 AT000155
6 · The paper itself

Abstract

Extracts of red clover (

Indexed as

IsoflavonesTrifoliumCaffeineCytochrome P-450 Enzyme SystemDietary SupplementsFemaleHumansCaffeineCytochrome P-450 Enzyme SystemIsoflavonesbotanical dietary supplementsclinical trialdrug interactionspharmacokineticsred clover

Identifiers

PMID33197178
PMCPMC8071351
OpenAlexW3103988848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.