Evidence map›Paper›PMID 33196997›Full record

SynthesisEnvironmental science and pollution research international2021

Pollutants and sperm quality: a systematic review and meta-analysis.

Damiano Pizzol, Carlo Foresta, Andrea Garolla, Jacopo Demurtas, Mike Trott, Alessandro Bertoldo, Lee Smith

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Sperm DNA Fragmentation: The Concept and Its Use in Assisted Reproduction.Advances in experimental medicine and biology · 2026
    Review
  9. FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Mapping Ethical, Legal, and Social Implications (ELSI) of gamete donation.Journal of assisted reproduction and genetics · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Damiano PizzolItalian Agency for Development Cooperation, 33 Street, Amarat, Khartoum, Sudan. damianopizzol8@gmail.com.ORCID http://orcid.org/0000-0003-4122-0774
Carlo ForestaUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Andrea GarollaUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Jacopo DemurtasClinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
Mike TrottThe Cambridge Centre for Sport & Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
Alessandro BertoldoZerouno Procreazione, Centro di Medicina, Venezia, Italy.
Lee SmithThe Cambridge Centre for Sport & Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
Anglia Ruskin University · GBUniversity of Padua · ITNorwegian Agency for Development Cooperation · NOUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male fertility and semen quality have declined over recent decades. Among other causes, exposure to environmental and occupational pollution has been linked to adverse reproductive outcomes, but effects on male semen quality are still uncertain. Therefore, the aim of the present study was to conduct a systematic review and meta-analysis to assess current evidence regarding the impact of exposure to tobacco smoke and environmental and occupational pollution on sperm quality in humans. In the meta-analysis, 22 studies are included showing that environmental and occupational pollutants may affect sperm count, volume, concentration, motility, vitality and sperm DNA, and chromatin integrity. All included articles reported significant alterations in at least one of the outcomes studied in association with at least one of the pollutants studied. Considering that sperm quality can be considered a proxy for general health and that pollutants have a dramatic impact on climate change, it would be strongly recommended to better understand the role of pollutants on human, animal, and planetary health.

Indexed as

Environmental PollutantsInfertility, MaleHumansMaleReproductionSemenSemen AnalysisSpermatozoaSperm CountSperm MotilityEnvironmental PollutantsMale infertilityPollutionSperm parametersSperm quality

Identifiers

PMID33196997
OpenAlexW3098614711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.