Evidence map›Paper›PMID 33196934›Full record

ArticleMedical oncology (Northwood, London, England)2020

Carboxyl-terminal polypeptide fragment of MUC16 combing stathmin1 promotes gallbladder cancer cell migration and invasion.

Kun Fan, Dexiang Zhang, Min Li, Sheng Shen, Jiwen Wang, Xiaojian Ni, Zijun Gong, Bohao Zheng, Zhihui Gao, Xiaoling Ni and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. siRNA-based strategies to combat drug resistance in gastric cancer.Medical oncology (Northwood, London, England) · 2024
    Review
  2. Review
  3. Article
  4. Article
  5. lncRNAMolecular therapy oncolytics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kun FanGeneral Surgery Department, Zhongshan-Xuhui Hospital Affiliated to Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-8795-8235
Dexiang ZhangGeneral Surgery Department, Zhongshan-Xuhui Hospital Affiliated to Fudan University, Shanghai, China.
Min LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Sheng ShenDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Jiwen WangDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Xiaojian NiDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Zijun GongDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Bohao ZhengDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Zhihui GaoDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Xiaoling NiDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China.
Tao SuoDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China. suo.tao@zs-hospital.sh.cn.
Han LiuDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Xuhui, Shanghai, China. liu.han@zs-hospital.sh.cn.
Houbao LiuGeneral Surgery Department, Zhongshan-Xuhui Hospital Affiliated to Fudan University, Shanghai, China. liu.houbao@zs-hospital.sh.cn.
Sun Yat-sen University · CNFudan University · CN

Funding

JianFeng Project of XuHui Provincial Commission of Health and Family Planning SHXH201703National Natural Science Foundation of China 81802751Shanghai Municipal Natural Science Foundation 16411952000
6 · The paper itself

Abstract

CA-125, coded by MUC16 gene, is responsible to many kinds of tumor metastasis. However, the related mechanism remains unclear. We have established a novel manner to reveal gallbladder cancer metastasis related to serum CA-125 levels through the C-terminal polypeptide of MUC16 gene production. MUC16 C-terminal polypeptide significantly promoted gallbladder cancer cell migration and invasion in vitro. Mass spectrum indicated that interaction of MUC16 C-terminal fragment with the C-terminal domain of stathmin1 inhibited the phosphorylation of stathmin1 to promote the combination with tubulin. Stathmin1 knockdown inhibited the migration and invasion of gallbladder cancer cells in vitro and lung metastasis in vivo induced by MUC16 C-terminal polypeptide. The high expression level of MUC16c consistent with stathmin1 was also confirmed in gallbladder cancer tissues. Our study revealed the underlying mechanism of gallbladder cancer metastasis related to CA-125 levels, which was beneficial for CA-125 in gallbladder cancer diagnose and therapy.

Indexed as

CA-125 AntigenCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionGallbladder NeoplasmsHumansMembrane ProteinsNeoplasm InvasivenessPeptide FragmentsStathminTubulinCA-125 AntigenMembrane ProteinsMUC16 protein, humanPeptide FragmentsStathminSTMN1 protein, humanTubulinGallbladder cancerMetastasisMicrotubuleMUC16 C-terminalStathmin1

Identifiers

PMID33196934
OpenAlexW3103612915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.