ArticleEuropean radiology2021
Obesity and muscle may have synergic effect more than independent effects on brain volume in community-based elderly.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Microbiota-Gut-Brain Axis Mechanisms in Cognitive Impairment Associated with Central Obesity.Current obesity reports · 2026Review
- Impact of physical activity and body mass index on brain structure: A cross-sectional MRI study.Journal of education and health promotion · 2025Article
- Effect of abdominal adipose tissue glucose uptake on brain aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- White adipose tissue distribution and amount are associated with increased white matter connectivity.Human brain mapping · 2024Article
- Identification of IGF-1 Effects on White Adipose Tissue and Hippocampus in Alzheimer's Disease Mice via Transcriptomic and Cellular Analysis.International journal of molecular sciences · 2024Article
- Ultrafast DCE-MRI for discriminating pregnancy-associated breast cancer lesions from lactation related background parenchymal enhancement.European radiology · 2023Article
- Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women.Journal of the American Geriatrics Society · 2023Article
- The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review.Frontiers in medicine · 2023Review
- The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development.Neurochemical research · 2022Review
- Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID-19.Obesity science & practice · 2021Article
- Association between ocular axial length and anthropometrics of Asian adults.BMC research notes · 2021Article
- Association between Visceral Fat and Brain Structural Changes or Cognitive Function.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the individual and combined effects of obesity and muscle mass on brain volume in a community-dwelling healthy older population.
methodsOne thousand two hundred nine participants (M:F = 574:635, mean age 63.6 ± 6.9 years) were included. The cross-sectional area of visceral fat (VF), the height-adjusted appendicular skeletal muscle mass (ASM/height
resultsOn regression analysis, TM/VF had a positive correlation to the volumes of temporal lobe and cerebellum. TM/VF was associated with volumes of 10 subcompartments. TM/VF was positively correlated with the volumes of left entorhinal cortex, right temporal pole and inferior temporal gyrus related to cognition (p < 0.05, respectively), and the volumes of cerebellum and right pallidum related to movement (p < 0.05, respectively). However, VF had a negative correlation to temporal lobe volume and ASM/height KEY POINTS: • If obesity and muscle mass were considered together, we could find more significant brain volume changes which were not found in obesity or muscle alone. • The ratio of thigh muscle to visceral fat was positively correlated with the volumes of entorhinal cortex, temporal pole, and inferior temporal gyrus related to cognition. • The ratio of thigh muscle to visceral fat was positively correlated with the volumes of cerebellum and pallidum related to movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.