Evidence map›Paper›PMID 33196856›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2021

Rate of continuing acute course treatment using right unilateral ultrabrief pulse electroconvulsive therapy at a large academic medical center.

James Luccarelli, Thomas H McCoy, Alec P Shannon, Brent P Forester, Stephen J Seiner, Michael E Henry

Open access · greenAbstract read
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Effects of Baseline Impaired Global Cognitive Function on the Efficacy and Cognitive Effects of Electroconvulsive Therapy in Geriatric Patients: A Retrospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

James LuccarelliDepartment of Psychiatry, Massachusetts General Hospital, 32 Fruit Street, Yawkey 6A, Boston, MA, 02114, USA. jluccarelli@partners.org.ORCID http://orcid.org/0000-0002-1606-3917
Thomas H McCoyDepartment of Psychiatry, Massachusetts General Hospital, 32 Fruit Street, Yawkey 6A, Boston, MA, 02114, USA.
Alec P ShannonDepartment of Psychiatry, Massachusetts General Hospital, 32 Fruit Street, Yawkey 6A, Boston, MA, 02114, USA.
Brent P ForesterDivision of Geriatric Psychiatry, McLean Hospital, Belmont, USA.
Stephen J SeinerDepartment of Psychiatry, McLean Hospital, Belmont, MA, USA.
Michael E HenryDepartment of Psychiatry, Massachusetts General Hospital, 32 Fruit Street, Yawkey 6A, Boston, MA, 02114, USA.
Harvard University · USMassachusetts General Hospital · USMcLean Hospital · US

Funding

A Randomized Controlled Trial of Electroconvulsive Therapy plus Usual Care versus Simulated-ECT plus Usual Care for the Acute Management of Severe Agitation in Alzheimer's Dementia (ECT-AD)R01AG061100 · NIA · MCLEAN HOSPITAL · PI FORESTER, BRENT PETER, PETRIDES, GEORGIOS · 2018 to 2023
$9.4M
Dysregulation of Appetitive & Aversive Amygdala Circuits in Bipolar DisorderR01MH120991 · NIMH · MCLEAN HOSPITAL · PI BERRETTA, SABINA, MCCARROLL, STEVEN ANDREW · 2020 to 2024
$4.0M
A Transdiagnostic Assessment of Electroconvulsive Therapy Modulation of Anhedonia and Reward circuitry: Targets, Biomarkers and Predictors of ResponseR01MH112737 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A · 2017 to 2021
$3.8M
Fostering Research Mentorship & Training during Psychiatry Residency SupplementR25MH094612 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO, GREENFIELD, SHELLY F. · 2011 to 2022
$2.3M
Machine learning for data-driven subtyping of major depressionR56MH115187 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PERLIS, ROY H. · 2018 to 2018
$596k
Brain and Behavior Research Foundation (US) NARSAD 26489National Institute of Mental Health (US) R56MH115187NIA NIH HHS 5R01AG061100-02NIA NIH HHS R01 AG061100NIMH NIH HHS 5R01MH112737-03NIMH NIH HHS R01 MH112737NIMH NIH HHS R01 MH120991NIMH NIH HHS R01MH120991NIMH NIH HHS R25 MH094612NIMH NIH HHS R25MH094612NIMH NIH HHS R56 MH115187
6 · The paper itself

Abstract

Right unilateral ultrabrief pulse (RUL-UBP) ECT has emerged as a promising technique for minimizing cognitive side effects of ECT while retaining clinical efficacy, but it is unknown how often patients will require alternative treatment parameters and at what point in the treatment course this occurs. To better define this problem, this study analyzes continuation in RUL-UBP ECT in a retrospective cohort of patients beginning acute course treatment. A single-center retrospective chart review was conducted of adult patients receiving a first lifetime course of ECT from 2010 to 2017 starting with RUL-UBP treatment parameters. 1793 patients met study criteria. Patients received a mean of 10.0 ± 3.2 ECT treatments, of which a mean of 8.4 ± 3.4 were RUL-UBP treatments; proportion using RUL-UBP through 12 treatments was 57.8%. In total, 65.6% of patients were treated with RUL-UPB ECT exclusively. Mean dose increased from 7.6 × seizure threshold at the second RUL-UBP treatment to 14.3 × seizure threshold at the twelfth RUL-UBP treatment. Rates of continuation in RUL-UBP ECT did not differ based on age or on primary diagnosis of major depression vs. bipolar disorder. Among patients beginning acute-course treatment using RUL-UPB ECT, two thirds were treated with these parameters exclusively. Among patients who received twelve RUL-UBP treatments, mean final dose was 14.3 × seizure threshold. Further studies regarding optimal dosing of RUL-UBP ECT are indicated.

Indexed as

Academic Medical CentersElectroconvulsive TherapyBipolar DisorderFemaleHumansMajor Depressive DisorderMaleMiddle AgedRetrospective StudiesSeizuresTreatment OutcomeCohort studiesElectroconvulsive therapySurvival analysisUltrabrief pulse

Identifiers

PMID33196856
PMCPMC7867629
OpenAlexW3104975705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.