ArticlePloS one2020
Visceral to subcutaneous fat ratio as an indicator of a ≥30% eGFR decline in chronic kidney disease.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nonlinear modeling of health checkup factors and future claims-based healthcare costs in Japan: a retrospective cohort study.Health economics review · 2026Article
- Association of anemia with long-term renal prognosis in autosomal dominant polycystic kidney disease using time-series analysis.Scientific reports · 2026Article
- Independent and combined associations of body mass index and visceral fat area with kidney function decline in a healthy Japanese urban population: a longitudinal study.BMC nephrology · 2026Article
- Modified Metabolic Syndrome Criteria Considering Cardio-Ankle Vascular Index (CAVI) and A Body Shape Index (ABSI): Implications for Kidney Risk.Reviews in cardiovascular medicine · 2025Review
- Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Lower body mass index potentiates the association between late-night dinner and the prevalence of proteinuria.Frontiers in endocrinology · 2025Article
- Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease.Insights into imaging · 2024Article
- Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease.Journal of nephrology · 2024Article
- Myosteatosis and aortic calcium score on abdominal CT as prognostic markers in non-dialysis chronic kidney disease patients.Scientific reports · 2024Article
- Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery.Frontiers in endocrinology · 2024Article
- Effect of the interaction between the visceral-to-subcutaneous fat ratio and aldosterone on cardiac function in patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Could METS-VF provide a clue as to the formation of kidney stones?Frontiers in endocrinology · 2023Article
- Visceral fat and attribute-based medicine in chronic kidney disease.Frontiers in endocrinology · 2023Review
- Association between metabolic scores for visceral fat and chronic kidney disease: A cross-sectional study.Frontiers in endocrinology · 2022Article
- Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Impact of visceral fat area in patients with chronic kidney disease.Clinical and experimental nephrology · 2021Article
- Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Whether the visceral-to-subcutaneous fat ratio (V/S ratio) is associated with renal prognosis in patients with chronic kidney disease (CKD) remains unclear. Furthermore, little is known about the effect of sex and the absolute amount of visceral fat accumulation such as visceral fat area (VFA) ≥100 cm2 on the V/S ratio in relation to renal prognosis. In this study, 200 patients with CKD were evaluated for renal prognosis. Survival analyses and logistic regression analyses were conducted, generating time-series pseudo-R2 values. The mean and percent change of the pseudo-R2 values from the 6th year to the 10th year (6Y-10Y Mean and 6Y-10Y Change, respectively) were calculated for determining the cut-off points for the medium-term renal prognosis. Multivariate Cox regression analysis revealed that the V/S ratio was significantly associated with renal outcomes and that the VFA category (VFA ≥ 100 cm2) had significant interactions with the V/S ratio regarding renal prognosis. The hazard ratio (HR) of the V/S ratio was higher in the sub-cohort of VFA < 100 cm2 than in the sub-cohort of VFA ≥ 100 cm2 (HR: 6.42 vs. 1.00). Regarding sex differences, a strong association was noted between the V/S ratio and renal prognosis in women but not in men (HR: 2.40 vs. 1.10). On the other hand, 6Y-10Y Mean of the pseudo-R2 values indicated differences in the cut-off points of the V/S ratio between men and women (V/S ratio: 0.75 vs. 0.5). Our findings indicate that it may be clinically meaningful to consider the differences in sex and the amount of VFA ≥100 cm2 for the V/S ratio in relation to renal outcomes in patients with CKD. The 6Y-10Y Mean of the pseudo-R2 values contributed to determining the cut-off points of the V/S ratio according to the sex difference.
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