Evidence map›Paper›PMID 33196296›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2021

Control of adipogenic commitment by a STAT3-VSTM2A axis.

Manal Al Dow, Maruhen Amir Datsch Silveira, Audrée Poliquin, Laura Tribouillard, Éric Fournier, Eva Trébaol, Blandine Secco, Romain Villot, Félix Tremblay, Steve Bilodeau and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
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  4. VSTM2A reverses immunosuppression in colorectal cancer by antagonizing the PD-L1/PD-1 interaction.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Manal Al DowCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Maruhen Amir Datsch SilveiraCentre de recherche sur le cancer de l'Université Laval, Université Laval, Québec, Canada.
Audrée PoliquinCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Laura TribouillardCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Éric FournierCentre de recherche sur le cancer de l'Université Laval, Université Laval, Québec, Canada.
Eva TrébaolCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Blandine SeccoCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Romain VillotCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Félix TremblayCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.
Steve BilodeauCentre de recherche sur le cancer de l'Université Laval, Université Laval, Québec, Canada.
Mathieu LaplanteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, Canada.ORCID 0000-0002-1752-6741
Institut universitaire de cardiologie et de pneumologie de Québec · CACentre hospitalier de l'Université Laval · CA

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en santé du Canada) 166168Gouvernement du Canada | CIHR | Institute of Health Services and Policy Research (IHSPR) 153318
6 · The paper itself

Abstract

White adipose tissue (WAT) is a dynamic organ that plays crucial roles in controlling metabolic homeostasis. During development and periods of energy excess, adipose progenitors are recruited and differentiate into adipocytes to promote lipid storage capability. The identity of adipose progenitors and the signals that promote their recruitment are still incompletely characterized. We have recently identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a novel protein enriched in preadipocytes that amplifies adipogenic commitment. Despite the emerging role of VSTM2A in promoting adipogenesis, the molecular mechanisms regulating

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAdipose Tissue, WhiteAnimalsCell DifferentiationGene Expression RegulationMaleMembrane ProteinsMiceMice, Inbred C57BLSignal TransductionSTAT3 Transcription FactorMembrane ProteinsStat3 protein, mouseSTAT3 Transcription FactorVSTM2 protein, mouseadipogenesisadipose tissuepreadipocytesSTAT3VSTM2A

Identifiers

PMID33196296
PMCPMC8260376
OpenAlexW3104425702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.