Evidence map›Paper›PMID 33196056›Full record

ArticlePatterns (New York, N.Y.)2021

KG-COVID-19: A Framework to Produce Customized Knowledge Graphs for COVID-19 Response.

Justin T Reese, Deepak Unni, Tiffany J Callahan, Luca Cappelletti, Vida Ravanmehr, Seth Carbon, Kent A Shefchek, Benjamin M Good, James P Balhoff, Tommaso Fontana and 8 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A change language for ontologies and knowledge graphs.Database : the journal of biological databases and curation · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. MetagenomicKG: a knowledge graph for metagenomic applications.bioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. The importance of graph databases and graph learning for clinical applications.Database : the journal of biological databases and curation · 2023
    Review
  19. KG-Hub-building and exchanging biological knowledge graphs.Bioinformatics (Oxford, England) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Justin T ReeseDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Deepak UnniDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Tiffany J CallahanComputational Bioscience Program, Department of Pharmacology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA.
Luca CappellettiDepartment of Computer Science, University of Milano, 20122 Milan, Italy.
Vida RavanmehrThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Seth CarbonDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Kent A ShefchekLinus Pauling Institute, Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
Benjamin M GoodDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
James P BalhoffRenaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA.
Tommaso FontanaDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, 20133 Milan, Italy.
Hannah BlauThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Nicolas MatentzogluIndependent Semantic Technology Contractor, London, UK.
Nomi L HarrisDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Monica C Munoz-TorresDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Melissa A HaendelLinus Pauling Institute, Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
Peter N RobinsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Marcin P JoachimiakDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Christopher J MungallDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Funding

CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EICHMANN, DAVID A. · 2017 to 2021
$28.9M
The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
Improvements to the LinkML framework to support the Phenomics First open science resourceRM1HG010860 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2020 to 2024
$10.3M
Technology Development for a MolBio Knowledge-BaseR01LM008111 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2004 to 2021
$9.7M
Illuminating the Druggable Genome by Knowledge GraphsU01CA239108 · NCI · JACKSON LABORATORY · PI MUNGALL, CHRISTOPHER J, OPREA, TUDOR I · 2019 to 2021
$1.7M
NCATS NIH HHS U24 TR002306NCI NIH HHS U01 CA239108NHGRI NIH HHS RM1 HG010860NIH HHS R24 OD011883NLM NIH HHS R01 LM008111NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

Integrated, up-to-date data about SARS-CoV-2 and COVID-19 is crucial for the ongoing response to the COVID-19 pandemic by the biomedical research community. While rich biological knowledge exists for SARS-CoV-2 and related viruses (SARS-CoV, MERS-CoV), integrating this knowledge is difficult and time-consuming, since much of it is in siloed databases or in textual format. Furthermore, the data required by the research community vary drastically for different tasks; the optimal data for a machine learning task, for example, is much different from the data used to populate a browsable user interface for clinicians. To address these challenges, we created KG-COVID-19, a flexible framework that ingests and integrates heterogeneous biomedical data to produce knowledge graphs (KGs), and applied it to create a KG for COVID-19 response. This KG framework also can be applied to other problems in which siloed biomedical data must be quickly integrated for different research applications, including future pandemics.

Indexed as

DSML 3: Development/Pre-production: Data science output has been rolled out/validated across multiple domains/problems

Identifiers

PMID33196056
PMCPMC7649624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.