Evidence map›Paper›PMID 33195826›Full record

ArticleBiochemistry and biophysics reports2020

L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells.

S V Stovbun, A S Vedenkin, A A Bukhvostov, L S Koroleva, V N Silnikov, D A Kuznetsov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

S V StovbunN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St., 4, Moscow, 119991, Russia.
A S VedenkinN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St., 4, Moscow, 119991, Russia.
A A BukhvostovN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St., 4, Moscow, 119991, Russia.
L S KorolevaInstitute of Chemical Biology & Fundamental Medicine, Siberian Branch of the RAS, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
V N SilnikovInstitute of Chemical Biology & Fundamental Medicine, Siberian Branch of the RAS, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
D A KuznetsovN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St., 4, Moscow, 119991, Russia.
Semenov Institute of Chemical Physics · RUSiberian Branch of the Russian Academy of Sciences · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect.

Indexed as

DNA Polymerase βDNA RepairHL-60Leukemial-thymidinePolydeoxyribonucleotides

Identifiers

PMID33195826
PMCPMC7644855
OpenAlexW3095661951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.