Evidence map›Paper›PMID 33195689›Full record

ArticleBioMed research international2020

A

Jun Yu, Yan Yan, Yiye Chen, Yan Zheng, Xiaoyan Yu, Jialu Wang, Yafu Wang, Anken Wang, Xiaoli Kang, Jie Cen and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jun YuDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-8198-0180
Yan YanDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, California 94303, USA.
Yiye ChenDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Yan ZhengDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Xiaoyan YuDepartment of Ophthalmology, The Fifth People's Hospital of Shanghai, Shanghai 200240, China.
Jialu WangDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Yafu WangDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Anken WangDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0003-4127-2400
Xiaoli KangDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-2829-3584
Jie CenDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0001-6834-4393
Lingyan DongDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-3101-1269
Li LiDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Affiliated Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0003-3076-5357
Peiquan ZhaoDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0001-6956-9359
Shanghai Jiao Tong University · CNChengdu Fifth People's Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to research the effects of glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) in rat Müller cells and the effects of an adenosine A

methodsThis study used RT-PCR and Western blotting to quantify the expressions of GS and GLAST under different hypoxic conditions as well as the expressions of GS and GLAST at different drug concentrations. A cell viability assay was used to assess drug toxicity.

resultsmRNA and protein expression of GS and GLAST in hypoxia Group 24 h was significantly increased. mRNA and protein expressions of GS and GLAST both increased in Group 1

conclusionsHypoxia activates GS and GLAST in rat retinal Müller cells in a short time

Indexed as

Adenosine A2 Receptor AntagonistsAmino Acid Transport System X-AGAnimalsCell SurvivalDisease Models, AnimalEpendymoglial CellsGlutamate-Ammonia LigaseHypoxiaPyrazolesPyrimidinesRats, Sprague-DawleyUp-RegulationAdenosine A2 Receptor AntagonistsAmino Acid Transport System X-AGGlutamate-Ammonia LigasePyrazolesPyrimidinesSCH 442416

Identifiers

PMID33195689
PMCPMC7641686
OpenAlexW3097078657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.