ArticleFrontiers in veterinary science2020
Pharmacokinetics of Oral Prednisone at Various Doses in Dogs: Preliminary Findings Using a Naïve Pooled-Data Approach.
Article in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Transcriptomic Effects of Oclacitinib and Prednisolone in an Acute IgE-Mediated Experimental Model of Canine Atopic Dermatitis.Veterinary sciences · 2026Article
- Hepatoprotective effects of mitoquinol mesylate in dogs with methylprednisolone acetate-induced steroid hepatopathy: A randomized crossover study.Veterinary world · 2026Article
- Article
- Efficacy and side effects of long-term treatment strategies of canine primary hypoadrenocorticism.Frontiers in veterinary science · 2025Article
- Kinetics and minimal inhibitory concentrations of ceftiofur in tear film following extended-release parenteral administration (ExcedeFrontiers in veterinary science · 2022Article
- Pharmacokinetics of Orally Administered Prednisolone in Alpacas.Frontiers in veterinary science · 2021Article
- Prednisolone pharmacokinetics in dogs with protein-losing enteropathy.Journal of veterinary internal medicineArticle
- Influence of medications on thyroid function in dogs: An update.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This pilot study aimed to determine the plasma pharmacokinetics of prednisone and its active metabolite prednisolone following oral prednisone administration in dogs-using dosing regimens that cover anti-inflammatory to immuno-suppressive biological effects. Six healthy Beagle dogs were given 0.5, 1, 2, and 4 mg/kg prednisone orally once daily for 5 days, each successive course separated by a washout period of 9 days. At steady-state (Day 4), a sparse sampling design allowed for collection of blood from 2/6 individuals for each of the following time points: 0, 15, 30, 60, 90, 120, 240, 480, and 720 min. Prednisone and prednisolone were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Oral prednisone was rapidly converted to prednisolone in dogs (≤ 30 min), with plasma prednisolone reaching ~6-fold greater levels (0-656.1 ng/mL) than prednisone (0-98.8 ng/mL) overall. The ratio of plasma prednisolone/prednisone was constant across the dosing regimens, indicating a non-saturation of the hepatic 11-β-hydroxysteroid dehydrogenase that converts the prodrug to the active metabolite in dogs. The level of both corticosteroids increased with increasing dosing regimens, albeit in a non-linear manner. Non-compartmental pharmacokinetic parameters are described, including peak concentration (C
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Registered trials
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