ArticleFrontiers in molecular biosciences2020
SARS-CoV-2 Virion Stabilization by Zn Binding.
Article in Frontiers in molecular biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin.PLoS pathogens · 2024Article
- The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin.European physical journal plus · 2023Article
- The two-stage molecular scenery of SARS-CoV-2 infection with implications to disease severity: An in-silico quest.Frontiers in immunology · 2023Article
- The zinc proteome of SARS-CoV-2.Metallomics : integrated biometal science · 2022Article
- A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs.Computers in biology and medicine · 2022Article
- Screening of Gene Expression Markers for Corona Virus Disease 2019 Through Boruta_MCFS Feature Selection.Frontiers in public health · 2022Article
- Serum Free Zinc Is Associated With Vaccination Response to SARS-CoV-2.Frontiers in immunology · 2022Article
- Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.ChemistryOpen · 2021Article
- A SARS-CoV-2 -human metalloproteome interaction map.Journal of inorganic biochemistry · 2021Article
- Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19.Cells · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
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