ReviewFrontiers in medicine2020
The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.
Review in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Predictors of rapidly progressive interstitial lung disease in anti-MDA5 dermatomyositis: a meta-analysis.Rheumatology (Oxford, England) · 2026Pooled it
- A Comparative Analysis of Aging Across Causes of Death.Evolutionary applications · 2026Article
- Integrated Bioinformatic Identification and Experimental Validation Reveal That Aging Exacerbates ARDS Through MAPK14/ADM/MAPK8 Axis.Journal of inflammation research · 2026Article
- Prevalence of occupational respiratory disease and its determinants among workers in major industrial sectors in Malaysia in 2023.Scientific reports · 2025Article
- Predictive modeling of ARDS mortality integrating biomarker/cytokine, clinical and metabolomic data.Translational research : the journal of laboratory and clinical medicine · 2025Article
- Trends and management of acute respiratory failure in hospitalized patients: a multicenter retrospective study in South Korea.Acute and critical care · 2025Article
- Article
- An interpretable machine learning model for predicting mortality risk in adult ICU patients with acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- Clinical Use of Nomogram Based on Machine Learning for Diagnosis Prediction of Acute Respiratory Distress Syndrome in Patients With Acute Pancreatitis.Mediators of inflammation · 2025Article
- Acute Respiratory Distress Syndrome: No Disease for Old Men.American journal of respiratory and critical care medicine · 2024Article
- Metabolic syndrome is associated with mortality in elderly patients with acute respiratory distress syndrome.Diabetology & metabolic syndrome · 2024Article
- Article
- Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review.Critical care (London, England) · 2024Review
- Driving pressure in mechanical ventilation: A review.World journal of critical care medicine · 2024Review
- Lower body mass index is an independent predictor of mortality in older patients with acute respiratory distress syndrome.Heliyon · 2024Article
- Article
- Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions.International journal of molecular sciences · 2023Article
- Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study.Respiratory research · 2022Observational
- Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.Microbiology spectrum · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Acute respiratory distress syndrome (ARDS) is associated with increased morbidity and mortality in the elderly population (≥65 years of age). Additionally, age is widely reported as a risk factor for the development of ARDS. However, the underlying pathophysiological mechanisms behind the increased risk of developing, and increased severity of, ARDS in the elderly population are not fully understood. This is compounded by the significant heterogeneity observed in patients with ARDS. With an aging population worldwide, a better understanding of these mechanisms could facilitate the development of therapies to improve outcomes in this population. In this review, the current clinical evidence of age as a risk factor and prognostic indicator in ARDS and the potential underlying mechanisms that may contribute to these factors are outlined. In addition, research on age-dependent treatment options and biomarkers, as well as future prospects for targeting these underlying mechanisms, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.