Evidence map›Paper›PMID 33195222›Full record

ArticleFrontiers in cell and developmental biology2020

Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells.

Ursula Kreuser, Justyna Buchert, Alexandra Haase, Wiltrud Richter, Solvig Diederichs

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  8. GRP94 is indispensable for definitive endoderm specification of human induced pluripotent stem cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
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  20. Factors underlying the association betweenGut microbiome (Cambridge, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ursula KreuserResearch Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.
Justyna BuchertResearch Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.
Alexandra HaaseLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover, Germany.
Wiltrud RichterResearch Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.
Solvig DiederichsResearch Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesodermal differentiation of induced pluripotent stem cells (iPSCs)

Indexed as

aggregationcartilagecell survivalextracellular matrixinduced pluripotent stem cellsWNT/β-catenin

Identifiers

PMID33195222
PMCPMC7661475

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.