Evidence map›Paper›PMID 33195213›Full record

ArticleFrontiers in cell and developmental biology2020

The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling.

Sek-Shir Cheong, Khondoker M Akram, Carlos Matellan, Sally Yunsun Kim, David C A Gaboriau, Matthew Hind, Armando E Del Río Hernández, Mark Griffiths, Charlotte H Dean

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. Article
  5. Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  13. Review
  14. Article
  15. Alveologenesis: What Governs Secondary Septa Formation.International journal of molecular sciences · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sek-Shir CheongNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Khondoker M AkramNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Carlos MatellanCellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London, United Kingdom.
Sally Yunsun KimNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
David C A GaboriauFacility for Imaging by Light Microscopy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.
Matthew HindNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Armando E Del Río HernándezCellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London, United Kingdom.
Mark GriffithsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Charlotte H DeanNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Imperial College London · GBRoyal Brompton & Harefield NHS Foundation Trust · GBSt Bartholomew's Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The

Indexed as

cell migrationfocal adhesionmechanosignalingplanar cell polarityRhoAtraction forceVANGL2YAP signaling

Identifiers

PMID33195213
PMCPMC7658195
OpenAlexW3097904862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.