ReviewFrontiers in chemistry2020
Recent Advances in Construction of Polycyclic Natural Product Scaffolds via One-Pot Reactions Involving Alkyne Annulation.
Review in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- [RhCp*ClACS omega · 2023Review
- Hydrazone modification of non-food natural product sclareolide as potential agents for plant disease.Heliyon · 2022Article
- One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli-Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems.Molecules (Basel, Switzerland) · 2022Article
- Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-Pharmaceuticals (Basel, Switzerland) · 2022Article
- Review
- Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress.Molecules (Basel, Switzerland) · 2022Review
- Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations.Chemical science · 2022Article
- 1,3,4-Oxadiazole Contained Sesquiterpene Derivatives: Synthesis and Microbiocidal Activity for Plant Disease.Frontiers in chemistry · 2022Article
- Base-Promoted One-Pot Synthesis of Pyridine Derivatives via Aromatic Alkyne Annulation Using Benzamides as Nitrogen Source.Molecules (Basel, Switzerland) · 2021Article
- Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides.ACS omega · 2021Article
- A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycyclic scaffolds are omnipresent in natural products and drugs, and the synthetic strategies and methods toward construction of these scaffolds are of particular importance. Compared to simple cyclic ring systems, polycyclic scaffolds have higher structure complexity and diversity, making them suitable for charting broader chemical space, yet bringing challenges for the syntheses. In this review, we surveyed progress in the past decade on synthetic methods for polycyclic natural product scaffolds, in which the key steps are one-pot reactions involving intermolecular or intramolecular alkyne annulation. Synthetic strategies of selected polycyclic carbocycles and heterocycles with at least three fused, bridged, or spiro rings are discussed with emphasis on the synthetic efficiency and product diversity. Recent examples containing newly developed synthetic concepts or toolkits such as collective and divergent total synthesis, gold catalysis, C-H functionalization, and dearomative cyclization are highlighted. Finally, several "privileged synthetic strategies" for "privileged polycyclic scaffolds" are summarized, with discussion of remained challenges and future perspectives.
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