ReviewDrugs1987
Side effects of cephalosporins.
Review in Drugs, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 130 citations in OpenAlex.
- The core mechanism of hypertension-linked renal fibrosis: "RAAS-ROS-inflammation-fibrosis" axis.iScience · 2026Review
- Comparing piperacillin/tazobactam to current guidelines for the treatment of open fractures: A systematic review.Journal of orthopaedics · 2025Review
- Article
- Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 virus.IUBMB life · 2020Article
- Quality assessment and cost saving of renal dosing recommendation by clinical pharmacists at medical wards in Thailand.International journal of clinical pharmacy · 2020Article
- Results of Intradermal Skin Testing with Cefazolin according to a History of Hypersensitivity to Antibiotics.Journal of Korean medical science · 2019Article
- Suspected Anaphylactic Reaction Prior to Induction of Anesthesia.Journal of lifestyle medicine · 2015Article
- Potential dual role of cephalosporins in management of alcohol use disorders.Psychopharmacology · 2014Article
- Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.Allergy, asthma & immunology research · 2014Review
- Immunologic evaluation of immediate hypersensitivity to cefaclor.Yonsei medical journal · 2014Article
- Fatal case of cephalexin-induced toxic epidermal necrolysis.SAGE open medical case reports · 2014Article
- Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.Clinical reviews in allergy & immunology · 2013Review
- [Problems of pharmacotherapy of infections in the aged].Der Internist · 2003Article
- The Treatment of Severe Group A Streptococcal Infections.Current infectious disease reports · 2003Article
- Effect of antibiotic treatment on vegetation size and complication rate in infective endocarditis.Clinical cardiology · 1997Article
- Cephalosporin utilisation review and evaluation.PharmacoEconomics · 1995Review
- A review of the adverse events profile of cefpirome.Drug safety · 1993Review
- Pharmacological properties of cephalosporins.Infection · 1991Review
- [Cefixime therapy in sinusitis].Infection · 1990Article
- Review of the pharmacology, pharmacokinetics, and clinical use of cephalosporins.Texas Heart Institute journal · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cephalosporins generally cause few side effects. Hypersensitivity reactions are less common than with the penicillins and modern studies have presented data contradicting a true cross-reactivity to cephalosporins in patients who have previously reacted to penicillins. Other hypersensitivity reactions to cephalosporins include fever, arthralgia and exanthema observed in two clusters of children who had been given cefaclor. Nephrotoxicity is not a problem with modern cephalosporins, although slight reductions of renal function have been seen when high doses of ceftazidime were used. Some of the new cephalosporins have a 3-methyl thiotetrazole side-chain, a moiety which confers a risk of reduced synthesis of prothrombin with subsequent risk of bleeding, and of disulfiram-like reactions in patients consuming alcohol following a cephalosporin dose. Other cephalosporins, e.g. ceftriaxone and cefoperazone, are excreted not only via the kidneys but also via the bile. This leads to high biliary concentrations of the active drug, increasing the risk of diarrhoea which may be caused by selection of cytotoxin-producing strains of Clostridium difficile. Laboratory adverse reactions to cephalosporins are rare. Eosinophilia and thrombocytosis are commonly reported, but are most probably not adverse reactions but signs of healing of the infections treated. Other haematological reactions have been reported in very few patients and have been rapidly reversible when treatment was stopped.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.