ArticleFrontiers in cellular and infection microbiology2020
Cytological and Histopathological Spectrum of Histoplasmosis: 15 Years of Experience in French Guiana.
Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Histoplasmosis in patients living with HIV in Europe: review of literature.Frontiers in microbiology · 2024Pooled it
- Synchronous Mucocutaneous Paracoccidioidomycosis and Oral Squamous Cell Carcinoma: Report of Two Rare Cases.Journal of cutaneous pathology · 2026Article
- Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum infections on tissue sections: Diagnostic pitfalls and relevance of an integrated histomolecular diagnosis.Medical mycology · 2024Article
- Pancytopenia and Progressive Breathlessness in a 48-Year-Old Man With a Reversed Halo Sign on Imaging.CHEST pulmonary · 2024Article
- Oral Granulomatous Disorders: A Diagnostic Insight.Cureus · 2024Review
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- Mucosal Leishmaniasis of the lip: Report of an Exuberant case in a Young man.Head and neck pathology · 2023Article
- A novel biosensor for ultrasensitive detection of fungal genes.Biosensors & bioelectronics · 2023Article
- An occurrence of intestinal histoplasmosis in a goat flock.Iranian journal of veterinary research · 2023Article
- Article
- A Simple Predictive Score to Distinguish between Disseminated Histoplasmosis and Tuberculosis in Patients with HIV.Journal of fungi (Basel, Switzerland) · 2021Article
- Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana.Journal of fungi (Basel, Switzerland) · 2021Article
- Reduced Severity in Patients With HIV-Associated Disseminated Histoplasmosis With Deep Lymphadenopathies: A Trench War Remains Within the Lymph Nodes?Frontiers in cellular and infection microbiology · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
Background: Disseminated histoplasmosis remains a major killer of immunocompromised patients in Latin America. Cytological and histological methods are usually present in most hospitals and may represent a precious diagnostic method. We report 15 years of experience of the department of pathology of the Centre Hospitalier de Cayenne Andrée Rosemon in French Guiana. Methods: Specimens from live patients from January 2005 to June 2020 with the presence of Results: Two hundred two cytological and histological samples were diagnosed with histoplasmosis between January 2005 and June 2020. The 202 samples included 153 (75.7%) histopathological formalin-fixed and paraffin-embedded tissues (biopsy or surgical specimens) and 49 (24.3%) cytological analysis from all organs. One hundred thirty-four patients (82.7%) were HIV-positive, 15 patients (9.3%) had immunosuppressant treatment, and 13 patients (8%) were immunocompetent. Seventy-eight of 202 (38.5%) were samples from the digestive tract, mostly the colon (53/78 cases, 70%) and small intestine (14/78 cases, 18%). Microorganisms were more numerous in digestive samples (notably the colon) than in other organs. Lymphocyte and histiocyte inflammation of moderate to marked intensity were observed in all positive specimens. Tuberculoid epithelioid granuloma were present in 16/78 (20,5%) specimens including 14 colon and 2 small intestine specimens. There were 11/202 cases of liver histoplasmosis, 26/202 (12,8%) cases of pulmonary histoplasmosis. Bone marrow involvement was diagnosed in 14 (2%) specimens (8 aspiration and 6 biopsies). Lymph nodes were positive in 42 specimens (31 histology and 11 cytology). Histopathological analysis of the 31 lymph nodes showed a variable histological appearance. Tuberculoid forms were most frequent (24/31, 77,4%). Conclusions: From the pathologist perspective, this is the largest series to date showing that digestive involvement was the most frequent, usually with a tuberculoid form and a greater load of
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