ArticleFrontiers in cellular and infection microbiology2020
Virome Sequencing of the Human Intestinal Mucosal-Luminal Interface.
Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- From gut dysbiosis to eubiosis: understanding microbiome recovery as an ecological process.Gut microbes · 2026Review
- Fecal virome at the human-animal interface: a one health perspective on an uncharted frontier.Animal microbiome · 2026Review
- The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features.Gut microbes · 2025Article
- DNA extraction and virome processing methods strongly influence recovered human gut viral community characteristics.bioRxiv : the preprint server for biology · 2025Article
- Gut virome: New key players in the pathogenesis of inflammatory bowel disease.World journal of methodology · 2025Review
- A rumen virosphere with implications of contribution to fermentation and methane production, and endemism in cattle breeds and individuals.Applied and environmental microbiology · 2024Article
- Hi-C metagenome sequencing reveals soil phage-host interactions.Nature communications · 2023Article
- Diversity of the microbiota communities found in the various regions of the intestinal tract in healthy individuals and inflammatory bowel diseases.Frontiers in immunology · 2023Review
- Landscapes of Enteric Virome Signatures in Early-Weaned Piglets.Microbiology spectrum · 2022Article
- Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome.Genome medicine · 2022Article
- The Role of the Human Gut Microbiome in Inflammatory Bowel Disease and Radiation Enteropathy.Microorganisms · 2022Review
- The Gut-Liver Axis in Cholestatic Liver Diseases.Nutrients · 2021Review
- Exploring Mucin as Adjunct to Phage Therapy.Microorganisms · 2021Review
- Article
- Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease.Frontiers in cellular and infection microbiology · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While the human gut virome has been increasingly explored in recent years, nearly all studies have been limited to fecal sampling. The mucosal-luminal interface has been established as a viable sample type for profiling the microbial biogeography of the gastrointestinal tract. We have developed a protocol to extract nucleic acids from viruses at the mucosal-luminal interface of the proximal and distal colon. Colonic viromes from pediatric patients with Crohn's disease demonstrated high interpatient diversity and low but significant intrapatient variation between sites. Whole metagenomics was also performed to explore virome-bacteriome interactions and to compare the viral communities observed in virome and whole metagenomic sequencing. A site-specific study of the human gut virome is a necessary step to advance our understanding of virome-bacteriome-host interactions in human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.