Evidence map›Paper›PMID 33194795›Full record

ArticleFrontiers in cellular and infection microbiology2020

Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs.

Pavel M Kopeikin, Maria S Zharkova, Alexander A Kolobov, Maria P Smirnova, Maria S Sukhareva, Ekaterina S Umnyakova, Vladimir N Kokryakov, Dmitriy S Orlov, Boris L Milman, Sergey V Balandin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Effects of Lipidation on a Proline-Rich Antibacterial Peptide.International journal of molecular sciences · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Pavel M KopeikinLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Maria S ZharkovaLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Alexander A KolobovLaboratory of Peptide Chemistry, State Research Institute of Highly Pure Biopreparations, Saint Petersburg, Russia.
Maria P SmirnovaLaboratory of Peptide Chemistry, State Research Institute of Highly Pure Biopreparations, Saint Petersburg, Russia.
Maria S SukharevaLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Ekaterina S UmnyakovaLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Vladimir N KokryakovLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Dmitriy S OrlovLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Boris L MilmanLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Sergey V BalandinScience-Educational Center, M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow, Russia.
Pavel V PanteleevScience-Educational Center, M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow, Russia.
Tatiana V OvchinnikovaScience-Educational Center, M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow, Russia.
Aleksey S KomlevLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Alessandro TossiDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Olga V ShamovaLaboratory of Design and Synthesis of Biologically Active Peptides, Department of General Pathology and Pathophysiology, FSBSI Institute of Experimental Medicine, Saint Petersburg, Russia.
Institute of Experimental Medicine · RUInstitute of Bioorganic Chemistry · RUState Research Institute of Highly Pure Biopreparations · RUSechenov University · RUUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proline-rich antimicrobial peptides (PR-AMPs) having a potent antimicrobial activity predominantly toward Gram-negative bacteria and negligible toxicity toward host cells, are attracting attention as new templates for developing antibiotic drugs. We have previously isolated and characterized several bactenecins that are promising in this respect, from the leukocytes of the domestic goat

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesGoatsMiceMicrobial Sensitivity TestsPeptides, CyclicAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntineoplastic AgentsbactenecinPeptides, Cyclicantibacterial activityantibiofilm activityantibioticsantitumor activitybactenecinsproline-rich antimicrobial peptidesstructure–activity relationshipsynergy

Identifiers

PMID33194795
PMCPMC7604311
OpenAlexW3093425706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.