Evidence map›Paper›PMID 33194657›Full record

ArticleFrontiers in oncology2020

Human Endogenous Retroviruses Long Terminal Repeat Methylation, Transcription, and Protein Expression in Human Colon Cancer.

Maria Dolci, Chiara Favero, Wafa Toumi, Evaldo Favi, Letizia Tarantini, Lucia Signorini, Giuseppe Basile, Valentina Bollati, Sarah D'Alessandro, Pietro Bagnoli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. Endogenous retroelements promote tolerance to dietary antigens.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Maria DolciDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Chiara FaveroEPIGET-Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Wafa ToumiLaboratory Services, Viral and Molecular Tumor Diagnostics Unit, Habib Thameur Hospital, Tunis, Tunisia.
Evaldo FaviRenal Transplantation, Fondazione Scientific Institute for Research, Hospitalization and Health Care Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Letizia TarantiniEPIGET-Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Lucia SignoriniDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Giuseppe BasileOrthopedic Department, San Siro Clinical Institute, Milan, Italy.
Valentina BollatiEPIGET-Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Sarah D'AlessandroDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Pietro BagnoliSurgical Department, Istituto Clinico Città Studi, Milan, Italy.
Pasquale FerranteDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Serena DelbueDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
University of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHabib hospital Thameur · TNIstituto Clinico Sant'Ambrogio · ITIstituto di Sessuologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon cancer is the fourth most common malignancy in both incidence and mortality in developed countries. Infectious agents are among the risk factors for colon cancer. Variations in human endogenous retrovirus (HERV) transcript and protein levels are associated with several types of cancers, but few studies address HERV expression in colon cancer. Fifty-eight patients with advanced-stage colon cancer were enrolled in this study. HERV-H, -K (HML-2), -P LTRs, Alu, and LINE-1 methylation levels and transcription of HERV-H, -K (HML-2), and -P

Indexed as

colon cancerHERV elementsHERV expressionhuman endogenous retrovirusesmethylation

Identifiers

PMID33194657
PMCPMC7653092
OpenAlexW3096394208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.