ArticleFrontiers in oncology2020
Pelvic Lymph Node Dissection During Cystectomy for Patients With Bladder Carcinoma With Variant Histology: Does Histologic Type Matter?
Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- TURBT versus RC in T1N0M0 non-urothelial bladder cancer: a population-based study.Frontiers in oncology · 2026Article
- A model for predicting overall survival in bladder cancer patients with signet ring cell carcinoma: a population-based study.European journal of medical research · 2023Article
- Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma.Journal of healthcare engineering · 2022Article
- Nomograms to predict individual prognosis of patients with primary signet ring cell carcinoma of the urinary bladder.Translational cancer research · 2021Article
- Young age increases the risk of lymph node positivity but improves prognosis in patients with bladder cancer treated via cystectomy: a population-based study.Translational andrology and urology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
purposeAdding pelvic lymph node dissection (PLND) to cystectomy offers significant survival benefit. However, it remains unclear whether this benefit persists in all histologic types. The aim of the study was to examine the impact of PLND on overall survival (OS) after cystectomy in bladder carcinoma patients with histological variants.
methodsWithin the Surveillance, Epidemiology and End Results database, we identified 16,880 bladder carcinoma patients receiving cystectomy between 2004 and 2015. Patients were stratified according to the following histologic types: transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, neuroendocrine carcinoma, signet ring cell carcinoma, pseudosarcomatous carcinoma, and other histology. Cox regression models were used to evaluate the effect of PLND on OS stratified by histologic type.
resultsHistologic types were significantly associated with the presence of lymph node metastasis in patients with bladder carcinoma ( DISCUSSION: Our analyses revealed a significant OS benefit from PLND in patients with transitional cell carcinoma, squamous cell carcinoma, and signet ring cell carcinoma. However, a survival benefit of PLND in patients with other histologic types was not demonstrated.
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