Evidence map›Paper›PMID 33194440›Full record

ArticlePeerJ2020

Tnni1b-ECR183-d2, an 87 bp cardiac enhancer of zebrafish.

Yawen Zhang, Feng Wang, Fang Wu, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Fish-Ing for Enhancers in the Heart.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yawen Zhang *Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
Feng Wang *Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
Fang WuTranslational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
Youhua WangDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xu WangCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
Yonghao GuiDepartment of Cardiology, Children's Hospital of Fudan University, Shanghai, China.
Qiang LiTranslational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNFudan University Shanghai Cancer Center · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral heart malformations are associated with mutations in the regulatory regions of cardiac genes.

methodsEvolutionary Conserved Region (ECR) Browser was used to analyze the 219 kb zebrafish and human genomes covering the

resultsCombined with comparative analysis and functional validation, we identified a 183 bp ECR (termed tnni1b-ECR183) that was located approximately 84 kb upstream of

conclusionsAn 87 bp cardiac-specific enhancer located 84 kb upstream of

Indexed as

Cis-regulatorsEvolutionary conserved regionTnni1bTranscription factorTransgenic zebrafish line

Identifiers

PMID33194440
PMCPMC7648457
OpenAlexW3097286824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.