ArticleMicrosystems & nanoengineering2020
Microneedle-based skin patch for blood-free rapid diagnostic testing.
Article in Microsystems & nanoengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 126 citations in OpenAlex.
- Advancing intradermal vaccine delivery: Focus on hollow microneedles and skin models.Human vaccines & immunotherapeutics · 2026Review
- Noninvasive malaria detection beyond blood sampling.Sensors & diagnostics · 2026Review
- Recent advances in interstitial fluid dynamics for diagnostic, targeted drug delivery and precision medicine applications.Drug delivery and translational research · 2026Review
- Microneedle-based platforms for wound healing: recent advances.Journal of materials chemistry. B · 2026Review
- Microneedle patch technologies in virology: bridging immunization, antiviral therapy, and point-of-care diagnostics.Clinical and experimental vaccine research · 2026Review
- Biomolecular profiling for noninvasive health monitoring.Nature biotechnology · 2026Review
- In situ electrochemiluminescence microneedle device for real-time biomarker monitoring in vivo.Nature communications · 2026Article
- A Comparative Single-Cell Atlas Reveals Pre-injury Signatures of Superior Healing in Oral Mucosa and Informing a New Paradigm for Wound Management.Functional & integrative genomics · 2026Article
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
- Controllable-pore porous microneedles for high-speed extraction and biomarker detection of interstitial fluid.Microsystems & nanoengineering · 2025Article
- Harnessing Polymeric Dissolvable Microneedles: Precision Delivery of Therapeutics for Oral Ulcers.ACS omega · 2025Review
- Microneedle-nanoparticle hybrid platforms for metabolic syndrome: advances in point-of-care diagnostics and transdermal therapeutics.Discover nano · 2025Review
- Recent advances and perspectives of MicroNeedles for biomedical applications.Biophysical reviews · 2025Review
- Microneedles at the Forefront of Next Generation Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A microfluidic wearable device for wound exudate management and analysis in human chronic wounds.Science translational medicine · 2025Article
- Motion artifact-controlled micro-brain sensors between hair follicles for persistent augmented reality brain-computer interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Advancing Melanoma Care: Microneedles for Diagnosis and Therapeutic Precision.Current pharmaceutical design · 2025Review
- Beyond Flexible: Unveiling the Next Era of Flexible Electronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Lateral Flow-Based Skin Patch for Rapid Detection of Protein Biomarkers in Human Dermal Interstitial Fluid.ACS sensors · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid diagnostic tests are one of the most commonly used tests to detect and screen for infectious diseases in the developing world. While these tests are simple, inexpensive, and readily available, they rely on finger-prick blood sampling, which requires trained medical personnel, poses risks of infection, and can complicate cooperation in young children, asymptomatic individuals, and communities with blood taboos. Here, we report a novel microneedle-based skin patch for the rapid detection of protein biomarkers in dermal interstitial fluid. Sample collection is facilitated by a hydrophilic hollow microneedle array that autonomously extracts and transports interstitial fluid to an antibody-based lateral flow test strip via surface tension for colorimetric antigen detection. We employ a simple gold enhancement treatment to enhance the detection sensitivity of this colloidal gold-based lateral flow assay and elucidate the underlying mechanism of this enhancement mechanism through experimental investigation. For proof-of-concept, this device was used to detect
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.