Evidence map›Paper›PMID 33194199›Full record

ReviewSAGE open medicine2020

Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer.

Mohammad Nurul Amin, Shafayet Ahmed Siddiqui, Md Ibrahim, Md Lukman Hakim, Md Salim Ahammed, Asma Kabir, Farhana Sultana

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in SAGE open medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 5 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 5 syntheses or guidelines pooled it, 226 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  13. Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?European archives of psychiatry and clinical neuroscience · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Effect ofFrontiers in medicine · 2026
    Article
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mohammad Nurul AminDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-8296-3542
Shafayet Ahmed SiddiquiDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
Md IbrahimCollege of Medicine, University of South Alabama, Mobile, AL, USA.
Md Lukman HakimDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Md Salim AhammedDepartment of Pharmacy, University of Information Technology and Sciences, Dhaka, Bangladesh.
Asma KabirDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
Farhana SultanaDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
Atish Dipankar University of Science and Technology · BDNorth South University · BDUniversity of Information Technology and Sciences · BDUniversity of South Alabama · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low molecular weight secreted by different cell types. They regulate intercellular communication and mediate a number of physiological functions in the human immune system. Numerous prospective studies report that inflammatory cytokines strongly predict coronary artery disease, myocardial infarction, heart failure and other adverse cardiac events. Inflammatory cascade is believed to be a causative factor in the development of atherosclerotic process. Several aspects of atherogenesis are accelerated by cytokines. This article provides an overall overview of current understanding of cytokines in various cardiovascular events. Besides, inflammatory cytokines trigger cellular events that can induce malignancy and carcinogenesis. Elevated expression of several cytokines such as interleukin-1, interleukin-6, interleukin-10, tumor necrosis factor-α, macrophage migration inhibitory factor and transforming growth factor-β are involved in tumor initiation and progression. Thus, they exert a pivotal role in cancer pathogenesis. This review highlights the role of several cytokines in various events of tumorigenesis. Actually, this article summarizes the contributions of cytokines in the pathogenesis of cardiovascular disease and cancer.

Indexed as

cancerscardiovascular diseasesCytokinesinflammation

Identifiers

PMID33194199
PMCPMC7594225
OpenAlexW3093770074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.