ArticleBritish journal of pain2020
Changes in peripheral and central sensitization in patients undergoing occipital nerve stimulation.
Article in British journal of pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06957873 (Evaluation of the Relationship Between Craniovertebral Angle and Fibromyalgia Symptom Severity), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Relationship Between Craniovertebral Angle and Fibromyalgia Symptom Severity
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Approaches to Occipital Neuralgia Treatment: A Systematic Review and Case Examples.Plastic and reconstructive surgery. Global open · 2026Article
- Real-world long-term outcomes of peripheral nerve stimulation: a prospective observational study.Pain management · 2025Observational
- Occipital nerve stimulation for cluster headache: lessons to learn from the 'voltage tuners'.The journal of headache and pain · 2024Article
- Combined Invasive Peripheral Nerve Stimulation in the Management of Chronic Post-Intracranial Disorder Headache: A Case Report.Clinics and practice · 2023Article
- Update of Neuromodulation in Chronic Migraine.Current pain and headache reports · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCentral sensitization and impaired conditioned pain modulation (CPM) response have been reported to contribute to migraine progression. Migraine patients can present with allodynia possibly attributed to increased sensitivity of peripheral ends of nociceptors with both peripheral and central sensitization. Occipital nerve stimulation (ONS) works by stimulating the distal branches of C1, C2 and C3 possibly altering the nociceptive traffic to the trigemino-cervical complex, brainstem and supranuclear connections.
aimsThis observational study explores peripheral and central sensitization in patients undergoing percutaneous ONS.
methodsFollowing local regulatory approval, 13 patients undergoing ONS with dual Octrode 90 cm leads and rechargeable implantable pulse generator (IPG) (St Jude) were recruited to have quantitative sensory testing (QST) pre- and post-procedure 2 weeks, 1, 3, 6 and 12 months.
resultsPatients with intractable migraine demonstrated impaired CPM (mean baseline pressure pain thresholds (PPTs): 61.98 kPa vs 48.01 kPa cuff inflated) prior to ONS, reverting to an efficient CPM response within 2 weeks following ONS implant (68.9 kPa vs 104.5 kPa cuff inflated) and continuing positively over the next 12 months. In contrast, no statistical difference was observed in PPTs.
conclusionThis is the first reported observation highlighting the effects on central sensitization following ONS. A consistent and sustained improvement in CPM was observed in contrast to PPT's where there was no difference. Normalisation of the CPM response following ONS indicates that the treatment may reduce central sensitization in the migraine population.
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