ArticleAmerican journal of translational research2020
Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 67 citations in OpenAlex.
- mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.Cancers · 2025Article
- Identification of 5mC regulatory factors mediating methylation patterns and prognosis models in head and neck squamous cell carcinoma.Discover oncology · 2025Article
- Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade.Biomolecules · 2025Review
- NSUN6 expression correlates with prognosis and immune infiltration in human cancers based on pan-cancer analysis.Scientific reports · 2025Article
- Detection, molecular function and mechanisms of m5C in cancer.Clinical and translational medicine · 2025Review
- Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers.Frontiers in oncology · 2025Review
- The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children.Frontiers in oncology · 2025Article
- The In Vitro Enhancement of Retinal Cell Viability via mInternational journal of molecular sciences · 2024Article
- Decoding the epitranscriptome: a new frontier for cancer therapy and drug resistance.Cell communication and signaling : CCS · 2024Review
- Review
- ALYREF/THOC4 expression and cell growth modulation in retinoblastoma.Pathology, research and practice · 2024Article
- The role of RNA-modifying proteins in renal cell carcinoma.Cell death & disease · 2024Review
- ALYREF-mediated RNA 5-Methylcytosine modification Promotes Hepatocellular Carcinoma Progression Via Stabilizing EGFR mRNA and pSTAT3 activation.International journal of biological sciences · 2024Article
- An ensemble learning-based feature selection algorithm for identification of biomarkers of renal cell carcinoma.PeerJ. Computer science · 2024Article
- Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics.Cancer metastasis reviews · 2023Review
- CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.Cell death and differentiation · 2023Article
- Identification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma.Scientific reports · 2023Article
- Identification and validation of a novel prognosis model based on m5C-related long non-coding RNAs in colorectal cancer.Cancer cell international · 2023Article
- Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape.Innovation (Cambridge (Mass.)) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHead and neck squamous cell carcinoma (HNSCC) is the fifth most common malignancy in the world. The 5-methylcytosine (m5C) plays vital roles in pathological conditions, such as cancer.
methodsThis study investigated The Cancer Genome Atlas (TCGA) database for patients with HNSCC. We characterized the mutations and copy number variations (CNVs) in m5C-regulatory genes, in addition to analyzing their mRNA expressions. Gene set enrichment analysis (GSEA) and protein-protein interaction (PPI) analyses were used to explore relevant functional annotations of m5C-regulatory genes.
resultsAlterations in m5C-regulatory genes were closely associated with patient clinicopathological characteristics. The expression of ten m5C-regulatory genes was significantly correlated with CNV patterns, indicating that m5C-regulatory genes have important regulatory effects. There was increased expression of m5C-regulatory genes, particularly ALYREF and NSUN5, during the tumor, node, and metastasis stages. Cox regression analysis revealed that the expression of DNMT1, TET2, and NSUN6 correlated with HNSCC prognoses. Furthermore, the expression of DNMT1 and ALYREF could effectively predict HNSCC risk in patients. In addition, the high expression levels of ALYREF correlated with mitochondrial function, and the elevated DNMT1 expression was associated with peptide cross-linking and humoral immunity. These results provide promising insight into the roles of m5C genes in tumor energy-metabolism and protein synthesis.
conclusionsCollectively, the results indicate that m5C plays critical roles in HNSCC progression, and is also a potential HNSCC prognostic marker.
Indexed as
Identifiers
33194076PMC7653571W3099638715What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.