Evidence map›Paper›PMID 33194029›Full record

ArticleAmerican journal of translational research2020

MiR-4644 is upregulated in plasma exosomes of bladder cancer patients and promotes bladder cancer progression by targeting UBIAD1.

Liang Yan, Qi Li, Ke Sun, Fan Jiang

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Liquid biopsy in bladder cancer: towards precision oncology.Journal of translational medicine · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Microrna Expression inMicroRNA (Shariqah, United Arab Emirates) · 2026
    Article
  7. The role of exosomes in bladder cancer immunotherapy.Journal of the National Cancer Center · 2025
    Review
  8. Article
  9. Review
  10. Bladder cancer: non-coding RNAs and exosomal non-coding RNAs.Functional & integrative genomics · 2024
    Review
  11. Advances in Liquid Biopsy for Diagnosis of Bladder Cancer.International neurourology journal · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. UBIAD1 protects against oxygen-glucose deprivation/reoxygenation injury via nNOS/NO pathway.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Liang YanDepartment of Urology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, China.
Qi LiDepartment of Urology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, China.
Ke SunDepartment of Urology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, China.
Fan JiangDepartment of Urology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosome-encapsulated microRNAs (miRNAs) have been identified as potential cancer biomarkers and pro-tumorigenic mediators for several cancers. However, the miRNA profiling in BCa-Exo (exosomes from plasma of patients with bladder cancer) has not yet been explored. Hence, the aim of this study was to analyze the miRNA profiling in BCa-Exo and to explore the function and mechanism of the selected miR-4644 in BCa progression. Of the 8 differentially expressed miRNAs in BCa-Exo relative to NC-Exo (exosomes from plasma of normal control subjects), hsa-miR-4644 was the only upregulated (fold change >2.0,

Indexed as

bladder cancerExosomemiR-4644UBIAD1

Identifiers

PMID33194029
PMCPMC7653622
OpenAlexW3103263512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.