Evidence map›Paper›PMID 33194015›Full record

ArticleAmerican journal of translational research2020

Aberrant expression of miR-16, B12 and CD272 in peripheral blood mononuclear cells from patients with active tuberculosis.

Dongzi Lin, Qiankun Liu, Wei Wang, Yanyun Li, Yumei Li, Bihua Lin, Ziyu Ye, Juan Huang, Xiaolin Yu, Yinwen Chen and 6 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Dongzi LinDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Qiankun LiuDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Wei WangDepartment of Laboratory Medicine, Foshan Forth People's Hospital Foshan 528041, Guangdong, China.
Yanyun LiDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Yumei LiDepartment of Laboratory Medicine, Dongguan Sixth People's Hospital Dongguan 523008, Guangdong, China.
Bihua LinDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Ziyu YeDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Juan HuangDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Xiaolin YuDepartment of Laboratory Medicine, Dongguan Sixth People's Hospital Dongguan 523008, Guangdong, China.
Yinwen ChenDepartment of Laboratory Medicine, Dongguan Sixth People's Hospital Dongguan 523008, Guangdong, China.
Yuezhi MeiDepartment of Laboratory Medicine, Dongguan Sixth People's Hospital Dongguan 523008, Guangdong, China.
Minyuan HuangDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Weiqin YangDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Jie ZhouDepartment of Laboratory Medicine, Foshan Forth People's Hospital Foshan 528041, Guangdong, China.
Xinguang LiuDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Jincheng ZengDongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University Dongguan 523808, Guangdong, China.
Guangdong Medical College · CNDongguan People’s Hospital · CNThe Fourth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) immunity is affected by complex immune regulation processes, which involve various immune cells, immune molecules, and cytokines. Here, we evaluated the expression of B12, CD272 and miR-16 in peripheral blood mononuclear cells (PBMC) of patients with active pulmonary tuberculosis. The results showed that monocytes expressing CD272 or B12 were down-regulated in patients with tuberculosis. The expression of B12 and CD272 in T cells and monocytes is related to tuberculosis. In TB patients, the up-regulation of miR-16 was negatively correlated with B12 mRNA expression, miR-16 was mainly expressed in CD14

Indexed as

B12CD272miR-16peripheral blood mononuclear cellsTuberculosis

Identifiers

PMID33194015
PMCPMC7653578
OpenAlexW3105296441

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.