ArticleOxidative medicine and cellular longevity2020
Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Effect of dexmedetomidine for prevention of acute kidney injury after cardiac surgery: an updated systematic review and meta-analysis.Renal failure · 2022Pooled it
- Efficacy and Safety of Intranasal Dexmedetomidine vs. Oral Chloral Hydrate for Sedation in Children Undergoing Computed Tomography/Magnetic Resonance Imaging: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Dexmedetomidine and acute kidney injury following cardiac surgery in pediatric patients-An updated systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Does dexmedetomidine reduce the risk of acute kidney injury after cardiac surgery? A meta-analysis of randomized controlled trials.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Review
- The effect of Dexmedetomidine on remote organ injury in the lung in rats with pancreatic ischemia reperfusion model.BMC anesthesiology · 2025Article
- Review
- Genomic Signals of Local Adaptation Associated With Environmental Variables inEcology and evolution · 2025Article
- Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review).International journal of molecular medicine · 2025Review
- Protective Effects of Dexmedetomidine and Amifostine Against Radiotherapy-Induced Kidney Injury.Life (Basel, Switzerland) · 2025Article
- Dexmedetomidine plays a protective role in sepsis-associated myocardial injury by repressing PRMT5-mediated ferroptosis.Toxicology research · 2025Article
- Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis.Frontiers in pharmacology · 2025Review
- Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats.Renal failure · 2024Article
- Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway.Redox report : communications in free radical research · 2024Article
- Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study.Discover oncology · 2024Article
- [Dexmedetomidine inhibits ferroptosis of human renal tubular epithelial cells by activating the Nrf2/HO-1/GPX4 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models.Inflammopharmacology · 2024Article
- Impact of a Dexmedetomidine Intravenous Infusion in Septic Dogs: Preliminary Study.Animals : an open access journal from MDPI · 2024Article
- Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway.Acta biochimica et biophysica Sinica · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress and apoptosis play a key role in the pathogenesis of sepsis-associated acute kidney injury (AKI). Dexmedetomidine (DEX) may present renal protective effects in sepsis. Therefore, we studied antioxidant effects and the mechanism of DEX in an inflammatory proximal tubular epithelial cell model and lipopolysaccharide- (LPS-) induced AKI in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.